Vol. 1 & Issue 1 ; Section B : Biological Sciences

Date : May. to Jul.2011

 

Synthesis and pharmacological properties of 4- (Substitutedbenzylidene)-2-phenyl-1-(5-(pyridin-4- yl)-1, 3, 4-thiadiazol-2-yl)-1H-imidazol-5(4H)-one

Sudhir Bhardwaj Narendra Parashar Manisha and Vandana Gurg

  • Abstract

    nonconventional technique for rapid organic synthesis in the last few years. Reactions in domestic microwave ovens are currently in use for the synthesis of medicinally important compounds. Within the framework of ‘Green Chemistry’ we have now developed an environmentally benign and novel approach for the synthesis of 4-(substituted benzylidene)- 2-phenyl-1-(5-(pyridin-4-yl) 1, 3, 4-thiadiazol-2-yl)-1H-imidazol-5(4H)-one. The title compounds were prepared by the reaction of 5-(pyridin-4-yl)-1, 3, 4-thiadiazol-2-amine with various 4-(substituted benzylidene)-2-phenyloxazol-5(4H)-one by using modified domestic microwave oven. The structure of these compounds was assigned on the basis of elemental analysis, IR, 1H NMR spectral data. The compounds showed significant antibacterialactivity against B. subtilis , S. aureus (gram-positive) and E.coli (gram-negative) bacteria and antifungal activity against C. albicans and A. niger fungi

Antioxidant activity of aqueous extract of Boswellia serrata

Ajay Sharma, Jitendra Upadhyay, Amit Jain, M. D. Kharya, Ajay Namdeo4 and K. R. Mahadik

  • Abstract

    This study was planned to investigate antioxidant activity of aqueous extract of Boswellia serrata (B. serrata) (Family - Burseraceae). Preliminary phytochemical screening indicates that the extract contain large amount of polysaccharides (30-35%). The aqueous extract shows free radical scavenging activity in a concentration dependent manner. At the concentration of 500 mg/mL, 94.6% diphenyl picryl hydrazyl, 80.9% nitric oxide, 40.97% hydroxide and 86.2% super oxide radicals were scavenged by the aqueous extract. At the concentration of 500 mg/mL extract shows maximum reducing ability (converting Fe3+ to Fe2+). The facts obtained in the current study implies that the aqueous extract of B. serrata have persuasive anti-oxidant activity in conflict to free radicals in a concentration dependent approach

Visible spectrophotometric method development and validation of aripiprazole in pure form

Mrs..V.V.Dhanu Radha, K.Rama Krishna

  • Abstract

    Two simple, economical and precise visible spectrophotmetric methods have been developed for the estimation of aripiprazole in pure form. These developed methods are based on the formation of yellow complex with sodium nitro prusside and bluish green complex with cobalt thio cyanate by using double distilled water. The maximum absorbance was observed at 430 nm and 625 nm for method 1 and method 2 respectively. Thus statistical analysis proves that the methods developed are reproducible and selective for the routine analysis of the said drug

  • Abstract