Vol. 3 & Issue 3 ; Section A : Chemical Sciences

Date : May. to Jul.2013

 

Electrochemical Reduction Behavior and Analysis of Aldicarb Sulfone

M.Pushpalatha.Chenna Rohini Kumara, K. Balajia, C.Sridevi and C.Suresh Reddy

  • Abstract

    Electrochemical reduction behaviour of Aldicarb Sulfone has been carried out, by employing d.c. polarography, cyclic voltammetry (CV) and differential pulse polarography (DPP) in the supporting electrolytes of the pH ranging from 2.0 to 12.0. Differential pulse polarography has been developed for the quantitative estimation of Aldicarb Sulfonein various environmental samples using standard addition method. The nature of electrode process was studied, the number of electrons was evaluated and the reduction mechanism was proposed. Kinetic parameters such as transfer coefficient, diffusion coefficient and heterogeneous forward rate constant are evaluated and reported. Quantitative determination was carried out in the concentration range 1.15×10-5 M to 2.20×10-8 M using a differential pulse polarographic method with a lower detection limit of 1.8×10-8 M.

Synthesis and Characterization of Layered Double Hydroxides

G.B. Pethe, J.D. Mahale, T.R. Lawankar and D.T. Mahajan

  • Abstract

    Layered Double Hydroxides (LDH) of like Mg (II) Al-NO3 and Zn(II) Al-NO3 have been prepared by co-precipitation method. They have been characterized by elemental analysis, powder X-ray diffraction, FTIR spectroscopy, TG-DTG and scanning electron microscopy. The X-ray analysis shows that both the cations (M2+ and M3+) were located in same layer and only carbonates and water are in interlayer. 1H-NMR studies revealed that water and carbonates are perpendicular to the layer. TGA analysis indicates formation of stable Mg-Al and Zn-Al metal oxides at 750°C. Various stoichiometric conditions have also been used for the synthesis of compounds.

A new analytical method development and validation for estimation of ciproflaxacin and metronidazole byiso absorption method by using UV – spectrophotometer

Natesh.G, MD.Azeez, Manoranjan Sabat, Goli.Venkatehwarlu, Nazia Begum and A.Srivani

  • Abstract

    A simple, validated and sensitive UV method has been developed for the estimation of ciprofloxacin and metronidazole. Literature review reveals that analytical methods like ion exchange chromatography, thin layer ion exchange chromatography are quite expensive comparative UV method .therefore present study has been under taken to develop an efficient UV method like Q- absorbance for the analysis of ciprofloxacin and metronidazole. After optimization of UV method, estimation and validation of method were done according to ICH guidelines. % RSD is found to be 0.601 and correlation coefficient were found to be 0.997 for metronidazole and 0.994 for forciprofloxacin .theλmax of ciprofloxacin and metronidazole are determined as 279nm and 313nm. From the overlay spectra the iso -absorptive point is obtained as 290nm .for estimation 279nm and 290nm are considered for calculation . from the standard graph it was revealed that the beer, s limit for both drugs follow the concentration range of 2-10μg/ml. this procedure was applied successfully

Synthesis and Physicochemical Studies of Benzimidazole and 2-Methyl Benzimidazole Derivatives

Falguni Karia, Jagdish Movaliya and Shipra Baluja

  • Abstract

    Some new benzimidazoline and methyl benzimidazolines have been synthesized. Further, physicochemical properties such as conductance, density and refractive index of these synthesized compounds have been studied in methanol and chloroform over a wide range of concentration at 298.15 K.

Synthesis, Characterization and Biological Activity of Pyrazolines

M.L.Leuva,V.M.Barot and Vikesh Agrawal

  • Abstract

    Title compounds 2-pyrazoline have been prepared by reaction of 1-(4- methyl-2, 5-dimethoxyphenyl)-3-(substituted-phenyl)prop-2-en-1-one(1a-e)which on treatment with hydrazine hydrate in presence of propionicacid to give 1-[3-(4- methyl-2,5-dimethoxyphenyl)-5-(substituted-phenyl-4,5-dihydropyrazol-1-yl]propan - 1-one (2 a-e).The structural assignment of the compounds was based on elements analysis and IR, 1H NMR and Mass spectral data. All the synthesized compounds have been screened for their antimicrobial activity to gram-positive and gramnegative bacterial strains and antifungal activity. The antimicrobial activities of the synthesized compounds have been compared with standard drugs like Amoxicillin, Ciprofloxacin and Griseofulvin. Purity of synthesized compounds have been checked by TLC.

Synthesis and Antimicrobial Activity of Pyrimidin-2-Thiones

M.L.Leuva,V.M.Barot and Vikesh Agrawal

  • Abstract

    Title compounds 2-pyrazoline have been prepared by reaction of 1-(4- methyl-2, 5-dimethoxyphenyl)-3-(substituted-phenyl)prop-2-en-1-one(1a-e)which on treatment with hydrazine hydrate in presence of propionicacid to give 4-(2,5- dimethoxy-4-methylphenyl)-1-(4-methylphenyl)-6-substitutedphenylpyrimidine- 2(1H)-thione (2a-e). The structural assignment of the compounds was based on elements analysis and IR, 1H NMR and Mass spectral data. All the synthesized compounds have been screened for their antimicrobial activity to gram-positive and gram-negative bacterial strains and antifungal activity. The antimicrobial activities of the synthesized compounds have been compared with standard drugs like Amoxycillin, Ciprofloxecine and Griseofulvin. Purity of synthesized compounds have been checked by TLC.

Novel Spiro Oxazoles Containing Triazolothiadiazines, Thiadiazines and Thiazines - Synthesis, Characterization and Biological evaluation

Vijay V. Dabholkar, Abhishek Karekar, N. B. Shinde & Prem Naik

  • Abstract

    A mixture of compound (1) and Glycine were refluxed in presence of acidic medium to yield compound (2) which further under bromination to give compound (3) Which on further treatment with Substituted 2-aminothiophenols, Substituted Thiocarbohydrazones and Substituted triazoles yields the respective benzothiazines, Thiadiazines, triazolo-thiadiazines, derivative(4a-6c). The structures of the products were confirmed by IR, 1H, 13C NMR and elemental analysis. Representative samples were screened for their anti-microbial activity against gramnegative

Comparative Study Of S-Substituted Triazinothiocarbamides In 60%, 70% And 80% Dioxane Water Mixture

Dipak T. Tayade and Ashwini M. Kshirsagar

  • Abstract

    In last four decades, S-triazine and thiocarbamide group containing drug create their own identity in the drug, pharmaceutical and medicinal sciences. The Interferometric measurements of recently synthesized drug have been carried out for solutions of 1-(4-hydroxy-6-methyl)-S-triazino-3-phenylthiocarbamide (L1) and 1-(4- hydroxy-6-methyl)-S-triazino-3-methylthiocarbamide (L2) at various concentrations. Hence, density and sound velocity of biologically important substituted triazinothiocarbamides were measured at 30°C in 60%, 70% and 80% dioxane-water mixture. The result obtained during this investigation directly through light on the dipole association of compound, intermolecular attraction between solute and solvent, dielectric constant of medium, polarizability and mutual compensation of dipoles, various acoustic/ thermodynamic parameters and useful for drug absorption, transmission, stability, activity and effect of these on drugs which is base of pharmacokinetics and pharmacodynamics of any drug. Taking all these things into consideration this research work was carried out.

Chromitite and the associated ultramafics of minor and Trace elements from South India at Tekuru and Kondapalli by PIXE technique

D.V.L.Sirisha

  • Abstract

    Multi-elemental analysis of samples is of great importance in research and mineral prospecting. Samples at regular depth intervals from south Indian mineral deposits . namely Tekuru Chromite deposit on the banks of River Godavari in West Godavari District, Andhra Pradesh are collected and accurate elemental analysis is performed on these samples. The amount of chromium was determined variable from 12.78% to 31.88% and iron percentage varies from 6.40% to 24.45% in the chromitites studied. The present work confirms the validity of non-destructive PIXE technique with reference to the study of chromite.

Chemistry of Novel Biphnyltetrazolo-Triazole Derivatives- Their Synthesis and Microbial Evaluation

Vijay V. Dabholkar, Navnath B. Shinde, Abhishek Karekar & Prem Naik

  • Abstract

    N-(triphenylmethyl)-5-(4'-bromoethylbiphenyl-2-yl)tetrazole reacted with ethyl piprazin -1-carboxylet to obtained (1), which on further treatment with chlorosulphonic acid to Triphenyl group & yield (2) ,this compound then treated with hydrazine hydrate to give hydrazine derivative (3) which was then treated with active methyl group , corbondisulphite, ethylchloroformet, aromatic cyno compound to yielded the respective pyrazole ,Oxadiazole,indazole&triazole. The structures of the synthesized compounds confirmed by Physico-chemical test and spectral techniques, representative samples screened for their antimicrobial activity against gram positive and gram-negative bacteria.

Synthesis, Structural Elucidation and Anti Microbial Screening of S-Triazinyl Substituted Aryl Amine Derivatives

Mahyavanshi Jyotindra  and Parmar Kokila .

  • Abstract

    A series of ten 2, 4, 6-trisubstituted s-triazines was synthesized with 4-Hydoxy benzonitrile, morpholine and different substituted arylamine derivatives methods. The title compound was then examined for their in vitro microbial activity against gram-negative bacteria and gram-positive bacteria and 2 fungal species. Structure of final compound was affirmed by IR,1H NMR,Mass Spectra and followed by elemental analysis.

Waste Coal Fly Ash Utilized For Removal of Sulphur Dye from Textile Waste Water: Kinetics and Equilibrium Study

Chavan S. K. and Paul S. A

  • Abstract

    A coal fly ash as an adsorbent used for removal of sulphur dye from textile wastewater. The coal fly ash required for present study collected from Bhusaval Thermal Power Plant district Jalgaon. The adsorption studies performed as a function of differen concentration of dye solution, contact time, pH and different adsorbent dosages. Thekinetics of the adsorption process follows the pseudo second-order kinetic model. Equilibrium data analyzed using Langmuir, Freundlich and Tempkin isotherm models. The suitability of the data in different model of isotherm is determined from correlationcoefficient (R2) value and maximum adsorption capacity values. The values of maximum adsorption capacity correlation coefficient (R2) for CAF was found to be 38.46 mg/g and close to one by using Langmuir model indicating that given adsorption isotherm best described by Langmuir model as compared to Freundlich and Tempkin model . The results showed that coal-fly ash a solid waste disposal from Thermal Power Plant can used as effective low cost adsorbent for removal of sulphur dye from textile wastewater.

Synthesis and Biological Studies of Co(II), Ni(II) and Cu(II) Complexes with ONNO Donor Coumarin Schiff Bases

Sangamesh A. Patil, ChetanT.P, and Prema S. Badami

  • Abstract

    The Schiff bases and their complexes of Co(II), Ni(II) and Cu(II) have been synthesized from 6-formyl-7,8-dihydroxy-4-methylcoumarin with o-phenylene diamine/ethylenediamine. The Schiff bases and their metal complexes structurally characterized based on IR, NMR, UV-visible, ESR, magnetic, thermal, and mass and ESI-MS studies. The complexes are soluble in DMF and DMSO and their molar conductance values indicate that complexes are non-electrolytic in nature. Elemental analysis reveals ML.2H2O [M = Co(II), Ni(II) and Cu(II)] stoichiometry, where ‘L’ stands for a doubly deprotonated ligand. The spectroscopic studies suggest the nitrogen and phenolic oxygen via deprotonation. Thermal studies suggest co-ordination of water molecule to the metal ion. The Schiff bases and their metal complexes have been screened for their antibacterial activity against the bacterial species, Escherichia coli, Pseudomonas auregenosa, klebsiella and Staphylococcus aureus, antifungal activity against the fungal species, Penicillium chrysogenum and Aspergillus niger. The anthelmintic activity of the synthesized compounds carried out using an adult Indian earthworm, Pheretima posthuma, due to its anatomical and physiological resemblance with the intestinal roundworm parasite of human beings.

Synthesis and antimicrobial screening of some new N1-citralidene hydrazido quinolin- 2(1H)-one derivatives

Pravina B. Piste, Shubhangi M. Kanase, Surekha B. Shevale and Maruti S. Kanase

  • Abstract

    Synthesis of desired compound involved carbethoxymethylation of 4- methyl quinolin-2(1H)-ones (III a-c) to form N1-carbethoxy methyl quinolin-2(1H)- ones (IVa-c) followed by hydrazine hydrate affords the corresponding N1-acetyl hydrazido 4-methyl-quinolin-2(1H)-ones (Va-c). The reaction of (Va-c) with citral (VIa-c). The structure of the synthesized compounds have been established on the synthesized compounds (Va-c) and (VIa-c) have been screened for their antimicrobial activities and found to possess significant antimicrobial activities.

Synthesis Characterization and Microbial Screening of 2-(4-Chlorophenyl-1, 3, 4-Oxadiazolyl)-5-thio-4- (Cyclohexylamino)-6-(arylamino)-S-triazine

Kokila A. Parmar, Sarju N. Prajapati and Chetan J. Vasava

  • Abstract

    A new series of 2-(4-Chlorophenyl-1,3,4-Oxadiazolyl)-5-thio-4- (Cyclohexylamino)-6-(arylamino)-S-triazine have been synthesized. The novel compounds structure has established based on their substituted aryl amine derivatives. All the compounds were characterized by FT-IR, and 1H-NMR spectroscopy as well as elemental analysis. These new compounds were evaluated for their in vitro antibacterial activity.

Spectroscopic characterization and thermal studies of bioactive nickel (II) and palladium (II) complexes with Schiff base ligands

Anant Prakash and Monika Agarwal

  • Abstract

    The new series of nickel (II) and palladium (II) complexes with different bidentate Schiff base ligands have been prepared and characterized by various spectroscopic as well as thermal studies. An infrared spectrum indicates coordination of metal ions through azomethine nitrogen and acetate/nitrate ions. The presence of water molecule(s) in the complexes has been supported by TG/DTA studies. Mass spectrum explains the successive degradation of the molecular species in solution and justifies ML complexes. Kinetic and thermodynamic parameters were computed from the thermal data using Coats and Redfern method, which confirm first order kinetics. The bio-efficacy of the complexes has been examined against the growth of bacteria in vitro to evaluate their anti-microbial potential. Molecular structure of the complexes has been optimized by MM2 calculations and suggests an octahedral/ square planar geometry.

Organic Solar Cell- The Future Energy Resource

Manish Kaushik and Bharat Kaushik

  • Abstract

    The limited supply of today’s main energy sources (oil, coal, uranium) will force us eventually to replace most of the currently used power plants with renewable energy sources. According to recent predictions, the inevitable permanent decline in the global oil production rate is expected to start within the next 10-20 years. The new category of renewable energy resource is Organic solar cell. Considerably less effort and production energy is necessary if organic semiconductors are used because of simpler processing at much lower temperatures (20-200 oC) than the inorganic cells. Another interesting alternative to inorganic cells is given by the semiconducting polymers, which combine the opto-electronic properties of conventional semiconductors with the excellent mechanical and processing properties of polymeric i.e. ”plastic”materials. These can be processed from solution at room-temperature onto e.g. flexible substrates using simple and therefore cheaper deposition methods like spin or blade coating. The advantage of polymeric photovoltaic cells when compared to electro-chemical cells is predominantly the absence of a liquid electrolyte, which generates problems with sealing against air, but also the prospect of even cheaper production using large area devices and the use of flexible substrates. Possible applications may range from small disposable solar cells to power smart plastic (credit, debit, phone or other) cards which can display for example, the remaining amount, to photo-detectors in large area scanners or medical imaging and solar power applications on uneven surfaces.

Oxidation and Reductive Elimination Reactions of Cyclopentadienyl with Interhalogens and Pseudohalognes

S.Jamal Haider Zaidi and Prem Raj

  • Abstract

    Interaction of cyclopentedienyl thallium have been conducted with iodine monobromide iodine monochloride and cyanogen bromide and cyanogen iodide give oxidative products CpTl IX (X= Br, Cl, I) which were found unstable. The reactions proceeded with the cleavage of CPTl IX to give CpX and Reactions of CpTl with diphenyl thallium and reactions of HCl with n-BuCl were also examined