Vol. 3 & Issue 4 ; Section A : Chemical Sciences

Date : Aug. to Oct.2013

 

Synthesis, Characterization and Antimicrobial studies ofn'-(1-(5-bromo-2-hydroxyphenyl) ethylidene)-2-oxo-2hchromene- 3-carbohydrazideand it’s metal complexes

K. Siddappa and Mallikarjun Kote

 

  • Abstract

    A new complexes of the type ML and M¢L [where M=Cu (II), Co (II), and Ni(II), Mn(II) and Fe(III) M¢=Zn(II), Cd(II) and Hg(II)]. L=N'-(1-(5-bromo-2- hydroxyphenyl)ethylidene)-2-oxo-2H-chromene-3-carbohydrazide (HL) Schiff base have been synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance, IR, 1H NMR, UV-Visible and ESR data. The studies indicate the HL acts as doubly Monodentate Bridge for metal ions and formmononuclear complexes. The complexes Ni(II), Co(II), Cu(II), Mn(II) and Fe(III) omplexes are found to be octahedral, where as Zn(II), Cd(II) and Hg(II) complexes are four coordinated with tetrahedral geometry. The synthesized ligand and its metalcomplexes were screened for their antimicrobial activity.

Synthesis And Characterization of Cr(III) And Cu(II) Complexes of HexaazabipyH2

Sulekh Chandra, Rajavally Prem and Smriti Raizada

  • Abstract

    A novel hexadentate nitrogen donor [N6] macrocyclic ligand, ie. Hexa azabipyH2 (L) has been synthesized. Cr(III) and Cu(II) complexes of this ligand have been prepared and characterized by elemental analyses, molar conductance measurements, magnetic susceptibility measurements, mass, 1H NMR (ligand), IR, electronic and EPR spectral studies. On the basis of molar conductance the Cr(III) complexes may be formulated as Cr(L)X3 and Cu(II) complexes may be formulated as Cu(L)X2, where X= Cl-, Br-, NO3 -, and CH3COO-. On the basis of IR, electronic and EPR spectral studies an octahedral geometry has been designated to Cr(III) and tetragonal for Cu(II) complexes.

On The Dipole Moment of Polar Molecules

Ruchitha Goonatilake and Raghuvarun Reddy Mutyala

  • Abstract

    In this experiment, the dipole moments of 1,2- and 1,3- dichlorobenzene were explored. This was done indirectly, by measuring the frequency to obtain the dielectric constant, and the index of refraction. The dipole moment of both molecules was determined using these values, through Hegestrand’s and Guggenheim’s methods. The values obtained from Hegestrand’s method were 2.77 D for 1, 2-dichlorobenzene and 1.89 D for 1, 3-dichlorobenzene. From Guggenheim’s method, the values of 0.21 D and 0.14 D were obtained for 1, 2- and 1, 3-dichlorobenzne, respectively. The dipole moment was found to decrease as the substituent’s been farther apart supporting the predictions. In addition, the data indicated that the experiment was performed with moderate success depicting its general trend.

2'-Hydroxy-4'-Butoxychalcone Oxime [HBCO] as a spectrophotometric reagent for the determination of Fe(III) ion in medicinal sample "Fefol".

Nilesh G. Limbachiya and K. K. Desai

  • Abstract

    The ligand 2'-Hydroxy-4'-butoxychalcone oxime (HBCO) was developed as a new analytical reagent for the spectrophotometric analysis of Fe (III) ion. In the pH range of 2.0 to 4.5 this reagent forms 70% aqueous ethanol soluble purple colored complex with Fe (III). Job's method of continuous variation and Yoe and Jone's mole ratio method revealed the stoichiometry of the complex to be 1:1 [M:L]. The obeyence of Beer's law was studied and the molar absorptivity was calculated. The reagent has been used to determine iron in medicinal sample "Fefol".

Acoustical Studies of Some Benzo[d]thiazole Derivatives in 1, 4-Dioxane and N, NDimethylformamide At 303.15 K

Shipra Baluja, Rahul Talaviya and Kapil Bhesaniya

  • Abstract

    The acoustical parameters of some synthesized benzo[d]thiazole derivatives have been studied from ultrasonic velocity and density measurements at different concentrations in 1,4-dioxane and N,N-dimethylformamide at 303.15 K. From these experimental data, some acoustical and apparent properties were evaluated. The results provide useful information about compound-compound and compound-solvent interactions and are of significant help in understanding the behavior of synthesized compounds in solutions.

Studies on Chalcone Derivatives Antioxidant and Stability Constant

R. Ravichandran, M. Rajendran, D. Devapiriam

  • Abstract

    The drug cis-platin development has raised new issues like metal complexes in biochemistry. The modeling of their biochemical properties involves the accurate determination of thermodynamically data, like stability constants. The chalcone 2’-hydroxychalcone and 2’-hydroxy-3,4-dimethoxychalcone have been synthesized and characterized with FT-IR,1H-NMR, 13C-NMR spectroscopic techniques. By using UV visible spectroscopy method the mole fraction ratio for Copper, Nickel and Zinc with 2-hydroxychalcone and 2’-hydroxy-3,4- dimethoxychalcone complexes were determined and it was found to be 1:1. The stability constants of this complex have been determined by Job’s method. The stability constant (Kf) of Copper, Zinc and Nickel with 2’-hydroxychalcone complexes in acetate buffer pH = 4.4 were determined to be 8.8 x 105 , 1.34 x 105 and 5.6 x 105 respectively. The Kf of Copper, Zinc and Nickel with 2’-hydroxy-3,4- dimethoxychalcone were determined at the same pH and that the values are 5.2 x 105 , 5.4 x 104 and 2.5 x 104 respectively. Antioxidant activity of these chalcones was evaluated by using 1,1’-diphenyl-2-picrylhydrazyl (DPPH) and 2,2’-Azino-bis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radicals scavenging methods, which showed that the antioxidant activity of 2’-hydroxychalcone has higher value than the 2’-hydroxy-3,4-dimethoxychalcone.

Ultrasonic Studies of Some Alkali Metal Chlorides in Aqueous Citric Acid at Different Temperatures

Shashi Kant and Manish Kumar

  • Abstract

    The density (ρ) and sound velocity (u) has been measured for LiCl, NaCl and KCl in 0.01 mol kg-1 aqueous citric acid solution at four different temperatures T =((303.15, 308.15, 313.15, and 318.15) K).These parameters were then used to obtain different acoustic functions such as adiabatic compressibility (β), intermolecular free length (Lf),specific acousticimpedance (Z), solvation number(SN) and molar compressibility(W). The ion- solvent and ion-ion interactions in the system have been discussed using these parameters. The effect of LiCl, NaCl and KCl on these interactions as well as on the solvent structure has also been discussed.

Microwave Assisted Synthesis of Some Bioactive Chalcones and Their Pyrazoline and Isoxazolines Derivatives

Deepika Rao, A. Wasi, Dr. SushilSahu and Bhupendra Kumar Sharma

  • Abstract

    Condensation of acetone with substituted benzaldehyde in presence of some basic alumina under microwave irradiation affords 1, 5-substituted diphenyl-1, 4-pentadiene-3-one chalcones. These chalcones undergo facile and clean cyclization with hydrazines RNHNH2 (R= Ph, C6H4 (NO2)2, CONH2, CSNH2) under microwave irradiation to afford 3, 5-arylated 2-pyrazolines in quantitative yields. The cyclocondensation of synthesized chalcones with hydroxylamine hydrochloride resulted in the formation of isoxazoline derivatives. The structures of all the compounds have been established on the basis of analytical and spectral data. All the synthesized compounds have screened for antibacterial and antifungal activity. Some synthesized compounds were found to exhibit excellent antibacterial and anti fungal activity. The results obtained indicate that, unlike classical heating, microwave irradiation results in higher yields in shorter reaction times and cleaner reactions.

A Comparative Study of Antimicrobial and DNA Clevage Activity of Metal(II) Complexes of Coumarin Derivatives.

Disha Tilala1, Manish Solanki, Denish Karia

  • Abstract

    New transition metal complexes of the composition, M[L(H2O)]2, where M= Fe(II), Ni(II), Co(II) and Cu(II); L= ligands prepared from 3-acetyl-4-hydroxy-8- methylpyrano[3,2-c]chromene-2,5-dione(LI) and 4-hydroxy-8-methyl-3-(3-oxobutyanoyl) pyrano [3,2-c]chromen-2,5-dione (LII), were synthesized and characterized by elemental analyser, conductivity measurement, IR, UV-Vis. and 1H-NMR spectral techniques. The low conductance data provide evidence for the non-ionic nature of the complexes. The antimicrobial activities of the ligands and their complexes have been studied by screening the compounds against the bacteria E. coli and B. megaterium and also the fungi C. albicans and A. niger. The data indicate that most of the metal complexes have higher antimicrobial activity than the free ligands. The DNA cleavage experiments, performed using gel electrophoresis with the corresponding metal complexes in the presence of H2O2 showed good results.

Oxidation of Zinc Complex (II) Derived from 8-Hydroxy Quinoline and Salicylaldehyde in Acid Medium: A Kinetic Study

Sayyed Hussain, Takale Surendra, Wankhede D. N.

  • Abstract

    The kinetic of oxidation of Zinc Complex (II) derived from 8-hydroxy quinoline and salicylaldehyde by potassium permanganate has been studied in the presence of acidic medium. The reaction is first order with respect to KMnO4 as well as Metal complex concentration. The reaction rate has been determined at different temperature and different thermodynamic parameters have been calculated which shows that the reaction rate increases with increase in temperature. With increase in the concentration of acid the reaction rate increase. A suitable mechanism has been proposed.

2'-Hydroxy-4'-Butoxychalcone Oxime [HBCO] as a Gravimetric and Spectrophotometric Reagent for the Determination of Pd(II).

Nilesh G. Limbachiya and K. K. Desai

  • Abstract

    The ligand 2'-Hydroxy-4'-butoxychalcone oxime (HBCO) was developed as a gravimetric and spectrophotometric reagent for the determination of Pd(II) ion. In the pH range of 2.0 to 5.0 this reagent forms 70% ethanol soluble yellow colored complex with Pd(II). Job's method of continuous variation and Yoe and Jone's mole ratio method revealed the stoichiometry of the complex to be 1:2 [M:L].The obeyence of Beer's law was studied and the molar absorptivity was calculated.

Microwave Assisted Synthesis and Biological Activities of Some α,β-Unsaturated Cyclohexanone and Their Pyrazoline, Isoxazolines Derivatives.

A. Wasi, Bhupendra Kumar Sharma , Ashish Kumar Gupta and Kumud Intodia

  • Abstract

    Condensation of cyclohexanone with substituted benzaldehyde in presence of neutral alumina under microwave irradiation affords substituted α,β‐ unsaturated cyclohexanone in quantitative yields. Which undergoes cyclization with hydrazines (Phenylhydrazine,2,4-dinitrophenyl hydrazine, semicarbazide and thiosemicarbazide) to afford a series of novel 7-(substituted benzylidene)-3-(substituted phenyl)-2- (substituted)-3, 3a, 4, 5, 6, 7-hexahydro-2H-indazole derivatives. Some new 7- (substituted benzylidene)-3-(substituted phenyl)-3, 3a, 4, 5, 6, 7-hexahydrobenzo[c] isoxazole derivatives were also synthesized in quantitative yields by cyclococondensation of substituted α, β‐ unsaturated cyclohexanone with hydroxylamine hydrochloride under microwave irradiation. The structures of all the compounds were confirmed by their analytical and spectral data. All the synthesized compounds were screened for antibacterial and antifungal activity. Almost all compounds have shown excellent activity against some Multi Drug Resistant bacteria.

Synthesis and in Vitro Antibactarial and Anti Fungal Activity of Trisubstituted S-Triazines

Anil Rathavi, Maharshi Shukla, M. K. Thakor

  • Abstract

    Ten compounds have been synthesized in a series of [1, 3, 5] triazine analogues which, in addition to 9-ethyl-9H carbazol-3-amine, contain morpholine and different Amines as well as piperidine substituents on the C-6 position of s-triazine ring. The title compounds were then evaluated for their in vitro microbial activity against 2 gram –Ve bacteria (E.coli, P. aeruginosa), 2 gram +Ve bacteria (S. aerues, B. subtilis) and 2 fungal species (C. albicans and A. niger). The most of the synthesized compounds have shown promising antimicrobial activity. All the final compounds were structurally elucidated on the basis of IR, 1H NMR, and other elemental analysis.

Synthesis and Antimicrobial Activity of Azetidin-2-one Containing Acetyl Pyrazoline Derivatives

Shailesh H.Shah, Niraj Shah, Pankaj S.Patel

  • Abstract

    Pyrazolines are very important Nitrogen containing five member heterocyclic chemical compounds and various methods have been worked out for their synthesis. A new series of 4-(4-Chloro phenyl)-3-chloro-1-{4-[5-(Substituted phenyl)-1-acetyl-4,5-dihydro-pyrazol-3-yl]phenyl}azetidin-2-one are synthesized by reacting 3-chloro-1-{4-[5-(Substituted phenyl)-4,5-dihydro-pyrazol-3-yl]phenyl}-4- (4-Chloro phenyl)azetidin-2-one (0.001M) with Acetic Acid in presence of Pyridine. All these compounds were characterized by means of their IR, 1H NMR, Spectroscopic data and pharmaceutical analysis. All the compounds were tested for their antibacterial and antifungal biological activities by broth dilution method

Polyethylene Glycol: Support as a Catalyst in the Synthesis of Novel Thiophene Chalcones

Asha Lavania, Manju Yadav, Kiran Dasary and Anita V K Anand

  • Abstract

    Chalcones with Excellent yields and purity were obtained in short time duration in the presence of Polyethylene glycol (PEG-400) which acted as a soluble polymer support and catalyst at low temperature. In present work, a series of novel chalcones (a-h) were prepared by Claisen-Schmidt condensation, by the reaction of 2-acetyl-5-chloro thiophene with different aromatic aldehydes in the presence of aqueous solution of sodium hydroxide, ethanol and PEG 400 used as a catalyst at room temperature. The structures of the various synthesized compounds are assigned on the basis of elemental analysis, IR, 1HNMR and mass spectral data.

Kinetic Study of Tungstophosphoric Acid Catalyzed Oxidative Degradation of Butane-2,3-Diol by N-Chlorosaccharin

S.K. Singh,H.D. Gupta, Gurpreet Kaur, Parampreet Kaur and , Ratan Kaur

  • Abstract

    The kinetics of oxidation of butane-2,3-ol by N-chlorosaccharin (NCSA)in presence of tungstophosphoric acid has been studied. The reaction follows identical kinetic being first order in each, NCSA, butane-2,3-diol, tungstophosphoric acid (TPA) and H+ concentration. The reaction is TPA and acid catalyzed. A negative effect of acetic acid is observed. Various thermodynamic parameters have been computed. Stoichiometric study revealed 1:1 mole ratio. On the basis of thermodynamic parameters and stoichiometry a plausible mechanism has been proposed and rate law has been derived.

Studies on Co-Ordination Polymers of 5, 5’-(6-(4- Chlorophenoxy)-1, 3, 5-Triazine-2, 4-Diyl)Bis (Azanediyl)Bis(2-Hydroxybenzoic Acid)

Kiran R.Chaudhari and J.A.Chaudhari

  • Abstract

    Co-ordination polymers of novel bis ligand namely 5,5'-(6-(4- chlorophenoxy)-1,3,5-triazine-2,4-diyl)bis(azanediyl)bis(2-hydroxybenzoic acid)(CSL- 2) have been prepared with various metal complexes viz Zn+2, Cu+2, Ni+2, Co+2 and Mn+2. The novel bis bidentate ligand (CSL-2) is synthesized by condensation of 5-amino salicylic acid with 2,4-dichloro-6- (4-chlorophenoxy)-1,3,5-triazine in presence of base catalyst. All these co-ordination polymers and parent ligand are characterized by elemental analysis, IR spectra and diffuse reflectance spectral studies for their structure determination.The thermal stability was evaluated by thermogravimetric analyses(TGA). In addition, all of the coordination polymers have been characterized by their magnetic susceptibilities. The microbicidal activities of all the samples have been monitored against plant pathogens.

Corrosion Resistance of Mild Steel Simulated Concrete Pore Solution in Presence of Carboxy Methyl Cellulose

Shanthi T and S. Rajendran S

  • Abstract

    Corrosion resistance of mild steel in simulated concrete pore solution (SCPS) Prepared in well water in the absence and presence of carboxy methyl cellulose (CMC) and Zn2+has been evaluated by weight loss method. It is observed that when CMC is added the corrosion inhibition efficiency (IE) increases. As the concentration of CMC increases, inhibition efficiency decreases. 50 ppm of CMC has 98% IE . 100 ppm of CMC shows 95% IE. When 50 ppm of Zn2+is added to the above system , both system shows 90% and 80% IE.The mechanistic aspects of corrosion inhibition have been investigated by polarization study and AC impedance spectra. The scanning electron microscopy (SEM) study confirms the protection of mild steel surface by strong adsorption of CMC.

Efficient acylation of phenols and amines under solvent free and catalyst free conditions

Deepa Panhekar , Ashok Kalambe  and Shridhar Satpute

  • Abstract

    Catalyst free and solvent free acylation of phenols and amines using acetic anhydride under microwave irradiation is reported. The acetate is obtained in high yield after a short reaction time compared to conventional method.

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