Vol. 4 & Issue 1 ; Section A : Chemical Sciences

Date : Nov.2013 to Jan.2014


Formation of Transition Metal Complexes Carrying MedicinalDrugs: Thermodynamic Study

ShailendrasinghVirendrasinghThakur, Mazahar Farooqui2and SahebraoD. Naikwade

  • Abstract

    Stability constant of Isoniazidand Imipramine Hydrochloridedrugs with transition metal ions Fe, Co, Ni, Cu, Zn and Cd have been determined by using a pH metric titration technique in 20% (v/v) ethanol-water mixture at three different temperatures (25°C, 35°Cand 45°C) and at an ionic strength of 0.1M NaClO4. The method of Calvin and Bjerrum as adopted by Irving and Rossotti has been employed to determine metal-ligand stability constant logK values. It is observed that transition metal ion forms 1:1 and 1:2 complexes. The thermodynamic parameters such as, Gibb’s free energy change (ΔG), entropy change (ΔS) and enthalpy change (ΔH) associated with the complexation reactions were calculated. The formations of metal complexes were found to be spontaneous, exothermic in nature and favorable at lower temperature.

Synthesis and Potentiometry Determination of Stability Constant of Binary Complex of Tetrapeptide TFA.Ala- Phe-Pro-Leu-OH with D-Block Transition Metals

Sanjay N. Aher a, b,, Supriya S. Aher b, S. D. Rathod

  • Abstract

    Tetrapeptide TFA. Ala-Phe-Pro-Leu-OH synthesized by using Solid phase peptide synthesis (SPPS). Proton-ligand formation constant (pK) of tetrapeptide have been evaluated by potentiometry measurements using Calvin-Bjerrum titration technique as used by Irving and Rossotti. The binary complex of Ni (II), Mn (II), and Fe (II) with tetra peptide are examined at varying temperature and ionic strength conditions in aqueous media. The stability of tetrapeptide metal complex with dblock transition metals follow the Irving-Williams order and shows inverse trend with varying temperature and ionic strength conditions

Performance of the Photogalvanic Cell for Solar Energy Conversion and Storage in Tween 60 – Thioflavine T – Ascorbic Acid System

K.R. Genwa and C.P. Sagar

  • Abstract

    The photogalvanic effect of Thioflavine T dye was proposed in H-cell consisting Tween 60–Thioflavine T–Ascorbic acid system. The maximum Photopotential of 934.0 mV with 90.0 μA of photocurrent was generated in cell. The experiments were performed in different pH conditions and dye concentrations. The system was found to generate maximum potential at pH 10.69. Photoreaction mechanism and effect of other factors were observed in detail. It is finally viewed that conversion based photogalvanic cell system has an additive advantage of low cost and good storage performance which makes this cost effective.

Potentiometry and Spectrophotometry Studies of Binary Complex of Tripeptide TFA.Leu-Ala-Phe- OH with Cu (II).

Sanjay N. Aher,a,b,, Supriya S. Aher b, S. D. Rathod

  • Abstract

    Tripeptide TFA.Leu-Ala-Phe-OH synthesized by using conventional solution phase peptide synthesis strategies. The proton and Cu (II) solution equilibrium investigation of tripeptide binary complex are studied by potentiometric and spectrophotometric measurements in aqueous media. Measurements were carried out at varying temperature and ionic strength conditions. Potentiometric studies performed by using Calvin-Bjerrum titration technique as used by Irving and Rossotti while spectrophotometric measurements performed to determine conditional stability constant (Log Kcond) by Jobs continuous variation method at pH 5.5. Both potentiometric and spectrophotometric data evaluation shows inverse trend with varying temperature and ionic strength conditions on the proton and Cu (II) binary complex stabilities in aqueous media.

Synthesis and Spectral Study, Theoretical Evaluation of new Binuclear Mn (II), Ni (II) and Cu (II) Metal Complexes Derived From Pyrane-2-one and its Biological Activity

Omar Hamad al-obaidi

  • Abstract

    The new acyclic Schiff base ligand[L]:3,3'-(1E,1'E)-1,1'-(2,2'-azanediylbis (ethane-2,1-diyl)bis(azan-1-yl-1-ylidene))bis (ethan-1-yl-1-ylidene) bis(4-hydroxy-6- methyl-2H-pyran-2-one) derived from condensation of one mole diethylenediamine triamine(dien)with two moles of dehydroacetic acid have behaved tetra dentate dibasic chelating agent with all metal ions understudy. Three bimetallic acyclic polydentate complexes [M2L2]Cl4 ,M=Ni(II), Mn(II) and Cu(II) have been prepared and fully characterized by FTIR, UV-Vis., micro-elemental analysis , as well as the magnetic moments of solid complexes and the measurements of molar conductance in DMSO solution helped us in investigate the chemical structure of bimetallic models. From the results obtained by different techniques, it was found that the proposed structures of the prepared complexes have tetrahedral structure. A theoretical treatment of the formation of complexes in the gas phase was studied; this was done using the HYPERCHEM-6 program for the Molecular mechanics and Semi-empirical calculations. The synthesized compounds were tested for antimicrobial activity by cup plate diffusion method. The results indicate the enhanced activity of metal complexes over the parent ligands.

Antioxidant and Metal Chelation Efficiency of Chalcone Derivatives

M. Rajendran and M. Thiruppathi Devi

  • Abstract

    Several chalcone derivatives have found pharmaceutical uses. During heavy metal stress phenolic compounds can act as metal chelators and on the other hand phenolics can directly scavenge molecular species of active oxygen. The antioxidant activity of chalcone was believed to increase due to electron donating substituent in the ring para position. Two chalcones have been synthesised by condensing 2’-hydroxyacetophenone with different aromatic aldehydes. The synthesized chalcones such as 2’-hydroxy-4-methoxychalcone (4MeC) and (2’-hydroxy-4-chlorochalcone (4ClC) can be used as antioxidant and chelating agent. The formation constants of chalcones of transition metal ions have been studied by using Job’s method. The chelating potential of the complexation of chalcones with Fe(II), Co(II), Ni(II) and Zn(II) was investigated by UV-Vis spectroscopy. The comparison of binding efficiency of the two chalcones 4MeC and 4ClC with various divalent metal ions reveals the fact that 4MeC has an increasing binding towards metals than the 4ClC. The antioxidant activity of these chalcones has been tested by adopting DPPH assay. It has been found that the 4MeC have higher antioxidant activity and metal chelation property than 4ClC. We have studied the properties of two chalcones, 4MeC and 4ClC, using semiempirical method using Parametric Model 3 (PM3) method and to understand the fundamental differences between the two molecules. The computed ionization potential and electron affinity showed that chalcones have a low molecular hardness and thus have a property to dissociate its phenolic –OH and the resulting charge undergoes delocalization throughout the structure. When the substituent group attached at the fourth position of.

A Novel Approach to Fabrication of ZnO Bulk and Nanostructures

M. C. Raoa, K. Ravindranadha and T. Rose Mary

  • Abstract

    Nanoparticles are of great scientific interest as they are effectively a bridge between bulk materials and atomic or molecular structures. A bulk material should have constant physical properties regardless of its size, but at the nanoscale size dependent properties are often observed. Thus, the properties of materials generally change as their size approaches the nanoscale and as the percentage of atoms at the surface of a material starts to become significant. ZnO is actually a wide band gap semiconductor of the II-VI semiconductor group. Because of its unique properties and versatile applications, it is used in transparent electronics, ultraviolet light emitters, piezoelectric devices and chemical sensors. There are various methods of synthesis of ZnO either in the form of bulk nanocrystal or in the thin film form, including bulk growth, substrate growth, chemical vapour deposition, sputtering and chemical route. The properties form the basis for motivation of device miniaturization; large effort has been focused on the fabrication, characterization and device applications of ZnO nanomaterials.

Determination of copper in various environmental samples using 4-dimethyl amino benzyl thiourea following solid phase extraction

L. Ramesh Babu & K.Kiran

  • Abstract

    The author successfully synthesized 4-dimethyl amino benzyl thiourea and it gives a yellow colored complex with copper metal solution in sodium acetate-acetic acid buffer of pH 5.5. Maximum absorption is found at 390 nm. Various factors such as pH, reagent concentration and choice of the solvent, foreign ions effects were studied. This method is successfully applied for the determination of copper in various environmental samples.

Stability Indicating RP-HPLC Method for Determination of Atenolol and Amlodipine Besylate in Tablets

Milind Ubale, Sayyed Husain and Vilas Chaudhri

  • Abstract

    A reverse phase method has been developed for the quantitative estimation of Atenolol and Amlodipine Besylate in Tablets. The Quantification was carried out using RP stainless steel column ODS C18 250 x 4.6 x 5 μ L1 packing in Isocratic mode with mobile phase containing 0.03 M Potassium buffer: Acetonitrile in the ratio of 50:50. pH 3.4 adjusted with ortho-phosphoric acid. Solution degassed before use. Flow rate maintained at 1.0 ml/minute and the detection wavelength was set at 237 nm. The linearity was found to be in the range of 16-22 μg/ml for Atenolol and 8 to 12 μg/ml for Amlodipine Besylate .The proposed method was found to be simple, precise, accurate, and reproducible for the estimation of Atenolol and Amlodipine Besylate.

Kinetics and Mechanism of the Formation of 5-Chlorosalicylidene-P-Toluidine

Bhausaheb K.Magar, Anil S. Kirdant and Trimbak K. Chondhekar

  • Abstract

    The second order reaction rate constant for the reaction of 5- Chlorosalicylaldehyde with p-toluidine have been reported in ethanol at temperature range 303 to 318 k .The rate of reaction is first order with respect to 5- Chlorosalicylaldehyde and p-toluidine. The rate of reaction increases with increases in temperature. The thermodynamic parameters are used to explain the nature of reaction. Suitable reaction mechanism has been suggested for the formation of the Schiff base. From the effect of temperature on the rate of reaction various thermodynamic parameter have been evaluated.

Assessment of Heavy Metal Bioaccumulation in Solanum Tuberosum L., Cultivated on Artificially Fed Medium

Renu Tyagi and Kalpana S.

  • Abstract

    Solanum tuberosum L. is grown worldwide along with India and used as a major part of food in various forms. Uptake of heavy metals by Solanum tuberosum L. is of immense importance because of toxic nature of most metals when their concentration exceeds permissible Limits. Present investigation is carried out to assess the bioaccumulation of Pb, Cd, Zn, Fe and Cu heavy metals in potato. For the purpose chosen variety of Solanum tuberosum L. is cultivated in five sets of different artificially contaminated soil, keeping all other condition controlled. The obtained tubers and corresponding soil were processed for heavy metal determination using Atomic Absorption Spectrophotometer. Correlation matrix has shown that most of the metal concentration in the tubers and the contaminated soil samples are significantly correlated.

Synthesis and In Vitro Antibacterial and Anti Fungal Activity of Trisubstituted S-Triazines

Anil Rathavi, Maharshi Shukla and M.K.Thakor

  • Abstract

    Ten compounds have been synthesized in a series of [1, 3, 5] triazine analogues which, in addition to 9-ethyl-9H carbazol-3-amine, contain different Amines. The title compounds were then evaluated for their in vitro microbial activity against two gram –Ve bacteria (E.coli, P.aeruginosa), two gram +Ve bacteria (S. aerues, B. subtilis) and two fungal species (C. albicans and. Niger). The most of the synthesized compounds have shown promising antimicrobial activity. All the final compounds were structurally elucidated on the basis of IR, 1H NMR, and other elemental analysis.

Redox Reactions of Cobalt (III) Complexes of Α-Hydroxy Acids by Nicotinium Dichromate in Surfactants

A.Nazim Ahmed, Mansur Ahmed, N.Sakthi Guru

  • Abstract

    The kinetics of one electron transfer mode seems to be unavailable for NDC with Cobalt (III) bound and unbound complexes of α-hydroxyacids in surfactant medium, NDC oxidizes Cobalt (III) bound and unbound α- hydroxyacids. It rules out the synchronous C-C bond fission and electron transfer to Cobalt (III) centre. Oxidation of above complexes increases with increase in temperature. The increase in the rate is observed with increase in the concentration of the surfactant. The added Cetylpyridinium chromate enhances the rate of oxidation of a reaction much more than ALS. Similar trends has been observed in lactato, glycolato and mandelatoCo (III) complexes

Synthesis, Characterization, Invitro and Insilico Drug Activity of Mixed Ligand Copper (II) Complexes

G.Valli and S.Gayathri

  • Abstract

    Copper(II) metal complexes can be derived from O-benzoyl benzoic acid and thiophene-2-aldehydethiosemicarbazone schiffbase and mixed ligand Copper(II) metal complexes have been synthesized and characterized in the light of UV, IR, and ESR spectral studies. The synthesized Copper(II) metal complexes have been screened for their invitro antimicrobial activities by zone of inhibition method against Escherichia coli. Pseudomonas Aeruginosa, Klebsilla Pneumoniae, Staphylococcus Aureus and Staphylococcus Epidermidis and also by insilico approach using Hex4.2 Software and PASS online software. The antimicrobial screening showed that [O-benzoylbenzoicacidato] [Salicylaldehydato] Copper (II) possessed higher activity towards S.Aureus and P.Aeroginosa. The docking score value of Cu (II) complexes showed that [O– benzoylbenzoicacidato] [Salicylaldehydato phenyl hydrazonato] Copper (II) possesses highest drug likness property against E.Coli, S.Aureus and S.Epidermis. PASS prediction showed the following activities like Maillard reaction inhibitor activity (94.1%), Phosphatase inhibitor, 3-Hydroxybenzoate 4-monooxygenase inhibitor, Glucose oxidase inhibitor, Interferon alpha agonist and Monodehydroascorbate reductase (NADH) inhibitor activities greater than 80%. Erythropoietin and antiviral (Arbovirus) activities were observed to be greater than 65%.

Inhibition Effect of Imidazole on Mild Steel in Binary Acid Mixture of (HNO3+HCl)

K. B. Patel and H. K. Kadiya

  • Abstract

    The corrosion inhibition of Imidazole on Mild Steel in (HNO3 +HCl) binary acid mixture was studied by weight loss, Temperature effect methods and polarization techniques. Corrosion rate increases with increase in concentration of mix acid. The inhibition efficiency of Imidazole increased as the concentration of Imidazole Increased. The inhibitor is found to be an excellent corrosion inhibitor from the results obtained. The adsorption of inhibitor on Mild Steel surface has been found to obey Langmuir adsorption isotherm. The inhibition action depends on the chemical structure, concentration of the inhibitor and concentration of the corrosive medium. The values of activation energy (Ea), free energy of activation (ΔG°ads), Heat of adsorption (Qads), enthalpy of adsorption (ΔH0ads) and entropy of adsorption (ΔS0ads) were calculated. Corrosion rate increases while I. E. decreases with rise in temperature.

Optimization of dispersive liquid-liquid micro extraction followed by HPLC-DAD determination of Cr (III) and Co (II) based on the complexation reaction with morpholin -4-carodithioate

A.Chehrehghania, N. Samadia, M. R. Vardast

  • Abstract

    In this study, a dispersive liquid-liquid microextraction (DLLME) method was used for preconcentration of Cr (III) and Co (II) cations in water samples. Morpholin -4- carodithioate (MDTC) was used as chelating agent prior to extraction. High-performance liquid chromatography-diode array detection (HPLC-DAD) was used for quantification of the analytes after preconcentration. The effects of extraction, nature and volume of disperser solvent, pH value of sample solution, extraction time and extraction temperature were investigated. Under the optimum conditions, the calibration graphs were linear in the range of (10-4000μg L-1) and (5-4000 μgL-1) with detection limits of 3 μg L-1 and 3 μg L -1 for Co(II) and Cr(III) respectively. Recoveries and enrichment factures for Cobalt and Chromium were obtained (90%, 63.69) and (84%, 58.42), respectively. The DLLMEHPLC-DAD method was successfully applied to the analysis of Cr (III) and Co (II) in aqueous samples.

Ethyl Paraben Derivatives as Future Potential Drug

Vijay D. Gangan, Ruchi S. Dubey, Chaitaly T. Chakraborty, Amod V. Tamhankar, Jagannath J. Kadam and Ajaykumar C. Singh

  • Abstract

    Parabens are class of chemicals widely used as preservatives in the cosmetic and pharmaceutical industries. They are effective preservatives in many types of formulae. These compounds and their salts are used primarily for their bacterial and fungicidal properties. They are also used as food additives. Their analogues viz. ethers and hybrid / fused molecules also possess various biological activities which prompted us to synthesize analogues for their future application as bioactive molecules. All the synthesized compounds were characterized by 1HNMR and mass spectral data and screened for their potential antibacterial activity against Gram+ ve and Gram– ve cultures. A Few of them are showing promising antibacterial activity.

Methyl Caffeate Ether Derivatives as Future Potential Drug

Lijy Jazlya, Vijay D. Gangana, Chaitaly T. Chakrabortya, Amod V. Tamhankarb, Jagannath J. Kadamc and Satish M. Bhalekard

  • Abstract

    Methyl (E)-3-(3, 4-dihydroxyphenyl) prop-2-enoate were treated with various alkyl halides in presence of K2CO3 and acetone to obtain their ether derivatives. Further methyl and ethyl ethers were also obtained using DMS and DES respectively. The structures of these compounds were confirmed by IR, NMR and Mass Spectroscopy. All the compounds give satisfactory elemental analysis. One of them shows promising Antibacterial activity.

Preparation and Characterization of Cyclic Metal (III) Derivatives (M = Ga, In)

S.Jamal Haider Zaidi and Prem Raj

  • Abstract

    Interaction of cyclobutane iodide at elevated temperature has been conducted with gallium and indium metals. The cyclic product is unstable, resulting in the formation of metal iodide which was converted to corresponding pyridine adducts, MI2Py these adduct metal pseudohalide afforded corresponding MX2PY. Where X= NCS, NCO.N3.The latter compounds were characterized by melting point, elemental analysis and infrared spectra.

Reactions of tris organoantimony (V) Derivatives with Hexaorgano dilead compounds

S.Jamal Haider Zaidi, Santosh Agnihotriand Prem Raj

  • Abstract

    Interactions of hexaaryldileads, Ar6Pb2 (Ar -Ph, p-tolyl) have been carried out with sterically hindered tris (α-naphtyl) and tris (cyclothexyl) derivatives of antimony of the general formula R3SbX2(R=C6H11,α-C10H7 X = Cl, Br. I, NCO, NCS and R3SbS) under moderate conditions. The mode of action and chemical behaviour of hexaaryldileads towards cyclohexyl and naphthyl antimony derivatives has been studied. The reactions proceeded with dehalogenation and desulphination of cyclohexyl and naphthyl derivatives.