Vol. 5 & Issue 2 ; Section A : Chemical Sciences

Date : Feb. 2015 to April 2015

 

Physico-chemical properties, lipids, glyceride and fatty acid compositions of mesta (Hibiscus cannabinus linn.) seed oil.

A. Akhter, M. MunsurRahman,M. A. Khaleque, Most. Halima Khatun and M. A. Rabbi

  • Abstract

    The physico-chemical properties, lipid, glyceride and fatty acid composition of mesta seed oil have been studied by the conventional methods. It was observed that the seed contains about 21% light yellow coloured oil. The total lipids were fractionated into three major lipid groups, neutral lipids, glycolipids and phospholipids by silicic acid column chromatography. The neutral lipid varied from 91.5-92.1%, glycolipid from 5.3-5.7% and phospholipid from 0.081-0.087% of the total lipid applied. The oil also fractionated into mono-, di- and triglyceride by silicic acid column chromatography. The triglyceride was varied from 91.5-92.8%, diglyceride from 2.0-2.8% and monoglyceride from 2.1-2.9%. The fatty acid composition of the oil was analyzed by GLC. The percentage compositions of fatty acid were found to be oleic acid (44.9), linoleic acid (25.3), palmitic acid (14.7) and stearic acid (6.2).

Docking studies of (e) -3-(2-chloroquinolin-3-yl)-1-(2-hydroxyphenyl) prop-2-en-1-one as anti-tuberculosis agents

M. R. Patle, A. M. Ghatole, A. K. Parmar

  • Abstract

    Mycobacterium tuberculosis is the single most deadly human pathogen and is responsible for nearly three million deaths every year1. Recent elucidation of the mode of action of frontline antimycobacterial drug, suggests that NAD metabolism is extremely critical for this micro-organism2. In the present study, the enzymes selected for docking which plays an important role in metabolism of tuberculosis. The enzymes is chorismate synthase. The enzymes of the shikimate pathway are potential targets for the development of new therapies because they are essential for bacteria but absent from mammals. The substituted 3-(2-Chloroquinolin-3-yl)-1-(2-hydroxyphenyl) prop-2-en-1-one molecules are found to be biological active5 against mycobacterium tuberculosis, whereas their molecular level interactions are not studied with chorismate synthase (2A86). The knowledge of exact interactions between ligand and enzyme helps in enhancing the biological activities by designing the new and potent anti-tuberculosis agents.

Synthesis of Lauha bhasma: γ-Fe2O3 nano particles and its Phase transformation studies

Tambur Pavani, K.Venkateswara Rao, Ch.Shilpa Chakra, Y.T.Prabhu

  • Abstract

    In the present research work, a novel and modern process is used to synthesize iron oxide nano particles (Lauha bhasma) with consecutive purification steps. Various media were used for processing by ayurvedic method. The synthesized samples were characterized using X-ray diffraction, to study how the purification steps influenced the structural properties of iron oxide nanoparticles. From X-ray diffraction it was observed iron oxide nanoparticles have cubic structure and Diffraction data lattice parameters, crystallite sizes, micro strains, cell volumes and porosities of the samples were calculated. A deeper study was made on the XRD studies by calculating the Lorenz Polarization Factor and Lorentz Factor.

Synthesis, Characterization and Antimicrobial Screening of Some Novel 3-(Naphtalen-1 and 2-yl) -5- Aryl-2- Pyrazolines Synthesized by Condensation of Hydrate Hydrazine to Appropriate α, β-Unsaturated Ketones

Assia Sid, Fatiha Mahdi, Amel Messai, Nouara Ziani and Mahieddine Mokhtari

  • Abstract

    Some new pyrazoline derivatives were synthesized by reacting appropriate α, β-unsaturated ketones with hydrate hydrazine in the presence of alcohol. The synthesized compounds were identified by spectral data and screened for antimicrobial activity. Some of these compounds showed moderate to considerable antimicrobial activity.

Synthesis, Characterization, Antimicrobial And Anticancer Activities of Mn(II) Mixed Ligand Complexes of Pentamethylene Dithiocarbamate With Diamines

D.Malathy and R.Vijayanthimala

  • Abstract

    A new series of binuclear Mn(II) mixed ligand complexes of pentamethylene dithiocarbamate(pmdtc)with diamines such as 1,10 phenanthroline (phen), ethylen ediamine(en),diethylenetriamine(dien),triethylenetetram ine(trien) are reported. The synthesized complexes were characterized by thermal, elemental, metal, nitrogen and sulphur, UV-Vis, infra-red, ESR Spectral analysis and magnetic susceptibility studies. Antibacterial, antifungal and anticancer studies have also been carried out on these complexes which show moderate activity towards some of the tested microaorgnisms.

Synthesis, Spectroscopic Characterisation and Biological Studies of Novel Co (II) Mixed Ligand Complexes of Piperidine Dithiocarbamate and Schiff Bases

Bharathi Krishnan and R.Vijayanthimala

  • Abstract

    Simple mixed ligand complexes of Cobalt(II) with piperidine dithiocarbamate and Schiff Bases derived from vanillin/Salicylaldehyde and amines such as ethylene diamine(en) and diethylenetriamine(dien), viz.salen,vanen and vandien, have been synthesized and characterized by elemental and thermal analysis, IR, UV-Vis and ESR spectral studies, and magnetic susceptibility studies. Antibacterial, Antifungal and Anticancer activities have also been carried out on these complexes, which indicates promising activity.

Packed Bed Modeling for Adsorptive Removal of Phenol

*S. J. Kulkarni and J. P. Kaware

  • Abstract

    Packed beds are used for adsorptive removal of various pollutants in the effluent treatment plants. Phenol and its derivatives can be removed by using various low cost adsorbents. Removal efficiency and percentage saturation of phenol in packed bed depends on the factors like initial concentration, flow rate and bed height. In the current research, groundnut shell carbon was used as an adsorbent in the packed bed. The data obtained in the experiments was fitted in two models namely Thomas model and Yoon Nelson model. The kinetic model parameters were computed for the data. During packed bed experiments, satisfactory removal of phenol was obtained. Effects of various factors like initial concentration, bed height and flow rate on model parameters were analyzed.

Synthesis and biological activity of some newly synthesized piperazinyl azlactone derivatives

Reena Rathore and Pramilla Sah

  • Abstract

    2-[(4’’-N-methyl piperazino)-3’-nitrophenyl]-4-benzylidine substituted oxazole-5-one derivatives (IV) were prepared by Erlenmeyer azlactone synthesis. For this N-methyl piperazine was treated with a chloro substituted acid leading to the formation of 4- (N-methyl piperazino)-3-nitro benzoic acid (I). Further reaction with sulphonyl chloride and glycine gave 4’-[(N-methyl piperazino)-3-nitro phenyl amido] acetic acid (III). Subsequent reaction with various aromatic aldehydes in presence of sodium acetate and acetic anhydride gave the title compounds. The structural elucidation of the compounds was determined by IR, 1H-NMR and antimicrobial activity was conducted by disc diffusion technique.The compounds have responded to E. coli, S. aureus, S. typhi and Candida albicans (in vitro) at 125 ug/disc and 250 ug/disc respectively.

Chemical composition and bioactive properties of Illicium verum (star-anise) extracts Prepared by different methods

Abeer F. Ahmad and Mervat S.H. Youssef

  • Abstract

    Star-anise (Illicium verum) has been widely used in many countries as a spice and for pharmaceutical treatment of many diseases. In this study, the effect of extraction methods (maceration and sonication) and solvents (ethanol and methanol) on antioxidant and antibacterial activity of star anise was investigated. The chemical components of star anise extracts were determined by GC-MS analysis. Total phenolic (mg galic acid/g), total flavonoid (mg quercetin/g) content, antioxidant activity (mg ascorbic acid/g) and reducing power (mg/ml) were evaluated in Illicium verum extracts, while antibacterial activity were evaluated by disk diffusion method. The main component identified in methanol extracts was anethole while, the main component of ethanol extracts was Caryophyllene. The highest amounts of total phenolic, total flavonoid content and total antioxidant activity were observed in ethanol ultrasonic extract. All Illicium verum extracts had antibacterial activity.

Experimental Evaluation of Antimicrobial Potentiality of Chemically Synthesized ZnS Nanoparticles

Sutapa Ganguly, Bidisha Ghosh, Sukhen Das, Sujata G. Dastidar

  • Abstract

    A high prevalence of multidrug resistances among pathogenic bacteria caused by indiscriminate and often inadvertent use of antibiotics for the past several years has necessitated search for new alternatives from different sources. Intensive studies have revealed that nanoparticles with their small size and high surface to volume ratio often possess distinct antimicrobial potentialities when compared to respective bulk materials. Nanoparticles of ZnS were synthesized by simple aqueous process with the help of cheap and ecofriendly precursors like ZnCl2 and Na2S. The sample was characterized by X-ray Crystallography (XRD) to determine the phase purity and average particle size. The morphology of sample surface was determined by Field Emission Scanning Electron Microscopy (FESEM). The XRD results revealed pure crystal structure of ZnS nanoparticles in powdered form. By FESEM ZnS nanoparticles were found to be spherical in shape and dispersed homogeneously with an average diameter of 29nm approximately. The in vitro antibacterial activity was carried out by agar dilution technique against 37 bacterial pathogens, belonging to both Gram positive and Gram negative types. It was found that strains of Staphylococcus aureus, Bacillus spp were inhibited at 50 μg/ml, while all the strains of Salmonella and Shigella were unable to grow at 100μg/ml of ZnS nanoparticles. Strains of E.coli, Klebsiella and Acinetobacter baumanii failed to grow at 200μg/ml of the material, while all the five strains of Pseudomonas aeruginosa were resistant to the ZnS nanoparticles.

Synthesis, characterization and biological studies of novel fused Benzothiazine derivative by Sonication technique

Vijay V Dabholkar, Omprakash G. Yadav, Navnath B. Shinde,Mustaqeem Mohammed A

  • Abstract

    An efficient approach for the synthesis of 6-(substituted) -2, 2-dimethyl-9H-1, 3-dioxa-10-thia-9-aza-anthracen-4-one by a one step condensation reaction of 1,3 dicarbonyl compound (Meldrums acid), aromatic primary amine and sulphur using catalytic amount of iodine refluxing in THF. All the synthesized compounds were preliminarily screened for their in vitro antimicrobial activity against Gram positive micro-organisms and Gram negative micro-organisms by disc diffusion method. The structural assignments are based on their elemental analysis and spectral data. 

An Assessment of Respiratory Symptoms from Inhalation of Particulate Matter in Urban and Rural Area of Nigeria

T.F. Ediagbonya, A.E. Tobin, E.E. Ukpebor and F.E. Okieimen

  • Abstract

    Industrialization with the increase in vehicular transportation and modernized life style equal the burgeoning increase in respiratory allergy in most countries. People who live in urban areas tend to be prone to respiratory diseases than those in rural areas. This study aims at investigating the pattern and the prevalence of respiratory symptoms and lung function using a structured questionnaire adopted from the MRC questions on respondents among residence in an urban and rural area in Southern Nigeria. A peak expiratory flow rate of the respondents was assessed by using a mini-Wright peak flow meter (Clements Clarke-London UK). During this study six hundred respondents were administered questionnaires which aimed at disclosing the frequency and duration of cough, production of phlegm, shortness of breath and occurrence of chest pain. The inhalable and respirable particulate matter captured exceeded the regulatory limit and the predominant symptom was difficulty in breathing. The anthropometric measurements: Weight, age and height were also done. The SKC XR5000 high volume gravimetric Sampler was used to capture the particulate matter (PM).

Efficient solvent-free synthesis of amidines using nano-Fe3O4 encapsulated-sillica particles bearing sulfonic acid

Navabeh Nami, Nasrin Nami

  • Abstract

    (Z)-N-[2-amino-1, 2-dicyanovinyl] formimidate 2 was obtained with the reaction of diaminomaleonitrile 1 and triethyl orthoformate. This compound was converted to aryl-(Z)-N-[2-amino-1, 2-dicyanovinyl] formamidines 3a-h under mild reaction and environmentally friendly method using Fe3O4@SiO2-SO3H (Sulfonic acid-functionalized silica-coated nano-Fe3O4) as a recyclable and magnetic catalyst in solvent-free condition.

Kinetics and Modeling of the adsorption of methylene blue by the grafted cotton

A. Kassale, K. Barouni, M. Bazzaoui, A. Albourine

  • Abstract

    The cotton grafted by succinic anhydride (AS) is used for the remove of methylene blue (M.B) from aqueous solution. Studies concerning the sorption kinetics (i.e. the effects of contact time, dye concentration) are discussed. A large adsorption capacity is observed: the order of 714 mg/g support grafted. In the present work we tested four equations insulated (Langmuir, Freundlich, Temkin and Generalized), and we have determined the characteristic parameters for each isotherm. The experimental results allow us to suggest the use of cotton registry by the succinic anhydride as adsorbent for the treatment of industrial waters.

Kinetics of Iodination of some α-aroyl Ketene Dithioacetal Derivatives by Iodine and Iodic Acid

Girish Deshmukh, Sarla Kalyankar, Mohan Kalyankar

  • Abstract

    The kinetics of iodination of the substituted α- aroyl ketene dithioacetals derivatives using iodine and iodic acid in ethanol has been studied under different conditions. These rates show first order kinetics in iodine and α- aroyl ketene dithioacetals and zero order with respect to iodic acid. The rates of reactions are measured at different temperature and activation parameters for all these. 

Synthesis and spectrophotometric study of complexation of Hg (II) with 2-[Phenyl – (Phenyl Hydrazino) – Methyl] Phenyl amine in Acetonitrile Solution

Samadi Naser and Azizi Heydarloo Sara

  • Abstract

    With respect to specious application of phenyl hydrazine and its derivative in organic Chemistry, Pharmacy and chemical industry. On its toxicity and biological effects, the 2-[Phenyl – (Phenyl Hydrazino) – Methyl] Phenyl amine are raised from interaction between 2-phenyl hydrazine and ceton in acid media. The constitution of this ligand is described below: presence of acetonitrile solvent in spectrophotometry the temperature is 25oC method using SHIMADZU 2550 devise a complex constitution is observed by strewing the Cu2+ cation with using a 10 microlitric syringe on a solvent made in a quartz cell (1cm), (that ligand with concentration of 5.8×10-4) This observation was using the molar proportions. for more confidence they used other ways such as jab method with stochiometric 1:1 and spectrum method FT-IR, FT-NMR that the devices names called SHIMADZU IR470, BRUKER 200 MHZ.

Synthesis, Spectroscopic Characterization and Antibacterial Studies of Co(II), Ni(II) and Cu(II) Complexes with Bis(Indolyl) Methane derived from 2-Methylindole and p-Vanillin

Souad Kasmi-Mir, Zahra Dembahri,  Nassiba Hayet Eddine Hadj Kouider, Khadidja Benhannour

  • Abstract

    The Bis (Indolyl) Methane (BIM) has been prepared from 2-methylindole and p -vanillin. The ligand was characterized by elemental analysis, IR, mass, 1HNMR, 13CNMR and electronic data. The Cobalt(II), Nickel(II) and Copper(II) complexes of the ligand (BIM) were prepared and characterized by analytical spectroscopic methods. The molar connductivity data reveal that the chelates are nonelectrolytes. The free ligand (BIM) and its metal complexes were screened for their antibacterial activities. The results indicated that the metal complexes are better antibacterial agents as compared to the free ligand BIM.

Kinetics of Iodination of some α-aroyl Ketene Dithioacetal Derivatives by Iodine and Iodic Acid

Girish Deshmukh, Sarla Kalyankar, Mohan Kalyankar

  • Abstract

    The kinetics of iodination of the substituted α- aroyl ketene dithioacetals derivatives using iodine and iodic acid in ethanol has been studied under different conditions. These rates show first order kinetics in iodine and α- aroyl ketene dithioacetals and zero order with respect to iodic acid. The rates of reactions are measured at different temperature and activation parameters for all these. 

Kinetic and Thermodynamic Study of Removal of Fluoride Ions from Water using Acid Treated Plant Materials

Satish Patil, Jayesh Patil, Naseema Patel

*

  • Abstract

    The study assesses the suitability of inexpensive natural adsorbents such as Jackfruit plant leaf powder (JPLP), Mangrove plant fruit powder (MPFP), Mango leaf powder (MLP), Teak tree bark powder (TTBP), Tamarind fruit shell powder (TFSP), Cinnamon plant leaf powder (CPLP) to effectively remediate fluoride-contaminated water by batch mode process. The efficiency of the sorption of fluoride ion is affected by pH, contact time, adsorbent dose, fluoride ion concentration, temperature, particle size of adsorbent and agitation speed. The adsorption kinetics has been found to follow first order rate mechanism for TTBP and TFSP but other adsorbents under study followed second order rate mechanism. Freundlich, Langmuir and Temkin isotherm models fit well for adsorption studies. Adsorption was found to increase with decrease in pH, decrease in particle size and increase in agitation speed. Desorption studies showed that regeneration of adsorbents are possible at higher pH. Thermodynamic analysis showed favorable, spontaneous and endothermic adsorption for MPFP and MLP but adsorption was found to be non-spontaneous and exothermic for JPLP, TTBP, TFSP and CPLP. MLP and MPFP were found to have excellent adsorption capacities towards fluoride ions.

On the Reactivity of Metal (loid) Halides (M = Hg, As, Sb and Te) Towards Hexa (penta- fluorophenyl) distannoxane [(C6F5)3Sn-O-Sn(C6F5)3] and Some Related Reactions

S.Jamal Haider Zaidi1 Kiran Singhal and Prem Raj

  • Abstract

    Interactions of metal(oid) halides,HgX2 ( X= Cl, Br), SbCl3, SbCl5, AsCl3 and TeCl4 with hexa(pentafluorophenyl)distannoxane [(C6F5)3Sn-O-Sn(C6F5)3] , at room temperature in diethyl ether/toluene proceeded with the simultaneous cleavage of the Sn-C and Sn-O bonds, invariably yielding(C6F5)2SnO along with other products. Thus the action of HgX2 (X=Cl,Br) on [(C6F5)3Sn]2O afforded polymeric bis(pentafluorophenyl)tin oxide,(C6F5)2SnO together with(C6F5)3SnX and C6F5HgX derivatives. The reactions of MCl3 (M=As, Sb) with [(C6F5)3Sn]2O yielded (C6F5)2SnO, C6F5MCl2 and (C6F5)3SnCl whereas the reaction of SbCl5 provided (C6F5)2SnO, (C6F5)SnCl2 and (C6F5)2SbCl3. Treatment of TeCl4 with[(C6F5)3Sn]2O yielded (C6F5)2SnO, (C6F5)3SnCl and C6F5TeCl3 at room temperature. The course of reaction indicated the instability of the Sn-O –M (M=Hg, Sb, As and Te) system proceeding via a four centered mechanism, providing organometal(loid) derivatives in profitable yield. The instability of Sn-O-Hg system is also reflected in the reaction of (C6F5)3SnCl with HgO which afforded (C6F5)2SnO and C6F5HgCl.Pentafluorophenyl-tin, -mercury and -antimony derivatives are also readily obtained by the cleavage reactions of (C6F5)4Sn with HgX2 and SbCl3 , respectively, in excellent yields. Pentafluorophenyl-tin and-mercury derivatives are also readily obtained by the cleavage reactions of (C6F5)4Sn with HgX2 and SbCl3.