Vol. 6 & Issue 2 ; Section A : Chemical Sciences

Date : Feb.2016 to Apr.2016

 

Electrical conductivity, optical properties and antioxidant activity of the hybrid [2,3-(CH3) 2C6H3NH3]6P6O18.2H2O

Ramzi Fezai, Ali Mezni and Mohamed Rzaigui

  • Abstract

    The present study reports investigation of Layers structure of the hybrid compound [2,3-(CH3)2C6H3NH3]6P6O18.2H2O. The impedance spectroscopy has been used to characterize this material in the temperature range 373-413 K. Electrical properties and dielectric measurements dependence on both temperature and frequency of this compound have been reported. The direct current conductivity process is thermally activated and the spectra follow the Arrhenius law with two activation energy 1.34 eV for T < 348 K and 0.72 eV for T > 348 K. The frequency dependence of AC conductivity follows Jonscher's universal law. The luminescent properties of this material have been carried out at room temperature based on UV absorption spectroscopy spectrum. This compound was also screened for its antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl radical and reducing power methods and with ascorbic acid as control. 

Sensitive and Selective Determination of Metronidazole Using Highly Luminescent Pepper Carbon Dots

Naser Samadi and Saeedeh Narimani

  • Abstract

    In this work High quality pepper carbon dot fluorescent sensor for determination of metronidazole is reported. The carbon nanoparticles were structurally and optically characterized by UV–vis absorption spectroscopy, photoluminescence (PL) emission spectroscopy and transmission electron microscopy (TEM). The calibrated curve was linear from 5×10−9 molL−1 to 7.5×10−3 molL−1for metronidazole. The detection limit was calculated as 2.9×10−9 molL−1. When adding other drugs and acide amines to the pepper carbon dot solution, fluorescence spectra of pepper did not change significantly but it had good selectivity toward metronidazole.The method presented here is simple, inexpensive, rapid, sensitive and an appropriate method for practical application. 

Lead (II) and Chromium (IV) Biosorption from Aqueous Solutions by Green Algae Spirogyra Sp.

N. Gupta, J. K. Shrivastava, A.K. Gupta

  • Abstract

    Heavy metal ion removal from aqueous solution or from wastewater by Biosorption Method is very cost effective and efficient Process. Results of metal ion removal from aqueous solution by using spirogyra sp. is presented here. Effect of pH, Time, Biosorbent Dose on the biosorption of heavy metals Pb(II) and Cr (VI) also described in this paper. Batch experiment were conducted to determine the biosorption capacity of spirogyra sp. and found results of maximum capacity of spirogyra sp. for lead is found to be 82% at pH 5and at pH 2 for Cr is 75% with algal dose of 5 gram at 250cC for both heavy metal ions. The effective pH Value for Pb (II) and Cr(VI) are found to be 5 and 5.5 , time required for metal uptake from wastewater was investigated for both metal ion and results found to be 90 minutes for Cr(VI) removal and 50 minutes for Pb(II)metal ion removal. Results shows that green algae spirogyra sp. is suitable biosorbent for the removal and with good recovery of Pb(II) and Cr(VI) from aqueous solution.

Natural Biosorbents: A Potential and Economic Alternative for Water Deflouridation

Pramod Kumar Awasthi, Sonu Sankhla and Dipti Mathur

  • Abstract

    Fluorine which is chemically most electronegative element is present in combined state as fluoride due to high chemical reactivity. Fluoride in minute quantity is essential component for normal mineralization of bones and formation of dental enamel but excess consumption causes to dental and skeletal fluorosis. Globally 32% of total world is suffering from fluorosis. Drinking water having fluoride more than 1.5 mg/L due to natural and anthropogenic activities is imposing serious threat to human health so the solution of fluoride contamination isurgently required. There are many techniques for removal of fluoride from water but most of them are expensive and not approachable to common people. Taking this in consideration there is need to introduce conventional method like fluoride adsorption which is cost effective and viable method in comparison to reverse osmosis and ion exchange method. This review discuss the role of some medicinal plants like Ocimum species, Moringaolifera, Leptadeniapyrotechnica, Vetiverzizanoids, Acacia catechu, Tinosporacordifolia and Tamarind as a biosorbent of fluoride from contaminated water.

Synthesis of Benzothiazole- Benzimidazole Thiazolidin Derivatives as Anti-Inflammatory and Analgesic

Mayank R Mehta, Satish Batra

  • Abstract

    A series of novel of 3-(2-((benzo[d]thiazol-2-ylthio) methyl)-1-benzyl-1Hbenzo[d]imidazol-6-yl)-4-iminothiazolidin-2-one were synthesized by cyclization of compound 6 and its series are formed by halogenated compound. We are well familiar that benzimidazole and benzothiazole derivatives are an important class of heterocyclic compounds. The attractive synthetic possibilities of these heterocyclic due to the presence of several reaction sites. Benzimidazole and Benzothiazole and their derivatives have attracted continuing interest over the years because of their vital role in biological area and are enormously essential with wide range of synthetic, pharmaceutical, and industrial applications. Maximum new drugs contain heterocyclic nucleus. So far, fused of thiazolidine in benzimidazole –benzothiazole modifications have showed highly effective with and lesser toxicity. The high therapeutic properties of this heterocyclic compound have encouraged scientist to synthesize a large number of novel drugs.

A Review on the Characterization of Metal Hydrazine Complexes

Raina O, AnjuthaPrabhaNandManimekalai R.

  • Abstract

    Hydrazine is apotential ligand and forms a widevarietyofcomplexes with variousmetalions, organicandinorganic acids. The emerging interests in these hydrazine complexes are mainly due to their structure and thermal behavior. An approach was made herein to review the characterizations such as Electronic spectra, Infra-red spectra (IR) and Thermogravimetric/Differential Thermogravimetric Analysis (TG/DTA) of mono metal and mixed metal hydrazine complexes with various acids.

Washing Study of Stained Woolen Fabric (Having Stains of Boot Polish and Hair Color Dye) With Coconut Oil Driven Amylase Loaded BSANPs as Bio-Active Nano-Wool Shampoo Additives

Kirti Rani

  • Abstract

    Amylase is used very significantly in textile, leather, paper and detergent industries for fabric washing, desiring of fabrics and starch processing due to having starch degrading property. In previous studies, amylase immobilization was done on to various biocompatible supports by adopting various methods to enhance its thermal and storage stability. Its immobilization onto albumin matrices such as bovine serum albumin (BSA) was observed to be very significant and low-cost enzyme Nano technique to prepare its non-toxic and low-cost amylase loaded BSA nanoparticles (BSANPs). In the proposed washing practice, coconut oil driven Cicer aritenium amylase loaded emulsified bovine serum albumin nanoparticles (BSANPs) were used and made bio-active with standardized 35U of alkaline protease for their biodegradation to allow the controlled release loaded amylase in reaction solution. Then, these bio-active amylase loaded BSANPs were used as nano-wool shampoo additives with chosen wool shampoo named, “Stergene Gentle Care” to test the stain removal efficacy from stained woolen fabric without affecting the delicacy and softness of the woolen fabric. In this washing study, chosen stains were comprised of daily routine stains of boot polish and hair color dye cream named, Cherry Blossom Shoe Polish Black and Garnier Nutrisse Nourishing color cream Black respectively. Sometimes, these routine stains are very tough to remove from the woolen/cashmere/merino/ mohair fabrics or required couple of pre-washing practices. So, keeping thisdomestic or industrial washing issue, these stains are selected very thoughtfully. And, from this washing study, effective washing findings were carried out to wash off the selected stains form woolen fabric when washed with chosen wool shampoo along with bio-active prepared coconut oil driven amylase loaded BSANPs solution as compared their washing with chosen wool shampoo alone. 

 Synthesis and Biological Evaluation of Novel Nonfused Heterocyclic Systems Derivatives Based On 5-(Alkylthio)-1, 3, 4-Thiadiazole-2(3H)-Thions

Elina N. Hambardzumyan, Asya S. Vorskanyan, Ani A. Grigoryan, Aleksandr P. Yengoyan

  • Abstract

    Convenient high yield methods for the synthesis of 33 novel 1, 3, 4-thiadiazolylthio-1,3,5-triazines and pyrimidines with various substituents are elaborated. The treatment of started 5-(alkylthio)-1,3,4-thiadiazole-2(3H)-thiones with 2,4-dichloro-6-alkyl(dialkyl)amino-1,3,5-triazines and 2,4-dichloro-6-methylpyrimidine led to 2-chloro substituted 4-((5-(alkylthio)-1,3,4-thiadiazol-2-yl)thio)-6-(alkyl(dialkyl)amino)-1,3,5-triazines and 4-((5-(ethylthio)-1,3,4-thiadiazol-2-yl)thio)-6-methyl-pyrimidine. The latter with trimethylamine formed the corresponding (pyrimidin-2-yl)-trimethyl-ammonium chloride. The reaction of this salt with methyl 4-hydroxybenzoate yielded 2-(4-methoxycarbonyl-phenoxy)-4-((5-(methylthio)-1,3,4-thiadiazol-2-yl)thio)-6-methyl-pyrimidine. The interaction of 2-chloro-4-((5-(alkylthio)-1,3,4-thiadiazol-2-yl)thio)-6-(alkyl (dialkyl) amino) -1, 3,5-triazines with thiourea and further treatment with KOH afforded 4-((5-(alkylthio)-1,3,4-thiadiazol-2-yl)thio)-6-(alkyl(dialkyl)amino)-1,3,5-triazine-2-thiols via intermediate 4-((5-(alkylthio )-1,3,4-thiadiazol-2-yl)thio)-6-(alkyl(dialkyl)amino)-1,3,5-triazin-2-ylcarbamimidothioate hydroch lorides. These thiols were easily alkylated into the corresponding alkyl derivatives.

Metal Based Triazole Schiff Bases: Synthesis, Characterization and Antimicrobial Activities

Kiran Singh, Sunita Raparia and Shashi Raparia

  • Abstract

    Coordination compounds of 1,2,4-triazole containing Schiff bases were synthesized and their structures were confirmed by elemental analysis, spectral and thermal studies. The enhanced fluorescence emission intensity on complexation reflects the versatile application chemistry of the metal complexes. From the ESR spectra of the Cu(II) complexes, the values of g║ and g┴ have been calculated and the observed values of g║ < 2.3 indicate covalent character of the metal ligand bond. Preliminary bioactivity studies against some bacterial and fungal strains were carried out to assess the role of metal ions on biological activity.

Isolation and Identification of Bioactive Compound from a New Strain of Trichoderma Harzianum and Estimate Its Bioactivity

Furdos, N.Jafar, Al-KamilM.L. and Al-Salihi, N.J.

  • Abstract

    solitary bioactive chemical compound was isolated and identified from marine isolate of Trichoderma harzianum isolated from the sedimentary coast of Arab gulf inFawregion in southern Iraq. The identification of this compound by using GC-Mass and H1NMR was confirmed. Solubility of compound in different solvents was tested and the toxicity of this compound against human blood showed a negative result. The molecular weights of the purified compound is 209kd. The chemical formula of compound is C11H15O3Nthus the chemical structure is 1-(indolin-3-yl) Propane-1,2,3-triol . The antimicrobial bioactivity of the purified compound against bacterial strains E. coli and S. aureusand against selected pathogenic yeasts and dermatophytic fungal isolates were tested using a disc diffusion agar method. The minimal inhibitory concentration (MIC) was also applied. Isolated compound exhibited good bioactivity against the tested bacteria and fungi. Molecular characterization of Trichoderma harzianum carried out by amplification of internal transcribed spacer- 1 region (ITS 1) of the ribosomal DNA by polymerase chain reaction (PCR). The amplified DNA was sequenced and aligned against using ex-type strains sequencings from TrichoBLAST/GenBank and established Trichoderma taxonomy.The data of sequence show that the studying isolate of T.harzianum is new starin.

Synthesis, Characterization, and Anticancer Evaluation of Novel Heterocycles Incorporating Benzimidazole

Asmaa S. Salman

  • Abstract

    Mannich reaction of 1,3-dihydro-2H- benzimidazole -2-thione derivatives 1a,b with morpholine and formaldehyde to give 2-(morpholin-4-ylmethylthio)-1H-benzimidazole derivatives 2a,b. Reaction 2H- benzimidazole-2-thione 1a with phenacyl bromide, acrylonitrile, and chloroacetic acid afforded 2- benzoylmethylthio-1H-benzimidazole 4, 3-(1H-benzimidazol-1-yl)propanenitrile derivative 7and [1,3]thiazolo[3,2-a] benzimidazol-3(2H)-one 8, respectively. One pot reaction of three compounds, 2H-benzimidazole-2-thione 1a, 1H-indole-3- carboxaldehyde or 1,3-diphenyl pyrazole-4-carboxaldehyde and chloroacetic acid afforded 2-[1H-indol-3-ylmethylene][1,3] thiazolo[3,2-a]benzimidazol-3(2H)-one 16 and 2-[1H-pyrazol-4-ylmethylene][1,3] thiazolo[ 3,2-a]benzimidazol-3(2H)-one 17.Reaction compounds 16 with cyanoacetic acid hydrazide, thiourea and ethyl cyanoacetate in the presence of TEA afforded pyrazole derivative 19 , pyrimidine derivative 20 and cyanopyrane derivative 21, respectively . Structures of the newly synthesized compounds have been confirmed by elemental analysis and spectral data .Some of the newly synthesized compounds were screened in vitro for their anticancer activities against human liver cancer cell line HepG2.

Synthesis and Spectral Studies of Metal Complexes of Substituted 2-Hydroxy Acetophenones-2- Pyridinyl Hydrazones

Suresh pal, R. S. Chauhan Ajay Sharma, Gayatri Prasad, Chetna Kumari Khatri and Kamal Kumar Mistry 

  • Abstract

    Metal complexes of substituted 2-Hydroxy Acetophenones-2 Pyridinyl Hydrazones were synthe- sized by relaxing a solution of appropriate legend (1 m Mol) in boiling ethanol (20 ml) with a solution of metal salt (1 m Mol) in ethanol (20 ml) or an aqueous solution of K2PtCl4 (1 m Mol) for two hours. The coloured crystalline solids of various shades were separated from the resulting solution at room temperature. The solids were filtered off, washed with ethanol and diethyl ether and dried over P4O10 under vacuum. Synthesized complex has characterized by elemental analysis, molar conductance, magnetic and spectral studies. Complexes are stable at room temperature and can be stored for a sufficient time without decomposing. All the complexes are freely soluble in DMF and DMSO.

Synthesis and Spectral Studies of Metal Complexes of Pyrazine-2-Carboxaldehyde-O-Hydroxyl Benzoyl Hydrazone (HPHBH)

Suresh pal, Ajay Sharma, Gayatri Prasad, Jaishree Gurnani, Santosh, Uma Vyas and R. S. Chauhan

  • Abstract

    Metal complexes of Substituted Pyrazine2carboxaldehydeohydroxy benzoyl hydrazone (HPHBH) were synthesized by refluxing a solution of appropriate ligand (1 m mol) in boiling ethanol (20 ml) with a solution of metal salt (1 m mol) in ethanol (25 ml) or an aqueous solution of K2PtCl4 (1 m mol) for 2 hours. The coloured crystalline solids of various shades were separated from the resulting solution at room temperature. The solids were filtered off washed with ethanol and diethyl ether and dried over P4O10 under vacuum. Synthesized complex have characterized by elemental analysis, molar conductance, magnetic and spectral studies. Complexes are stable at room temperature and can be stored for a sufficient time without decomposing. All the
    complexes are freely soluble in DMF and DMSO. 

Polyaniline: Synthesis, Characterizations and Study their Antibacterial Activity against Escherichia Coli

Rebaz A. Omar, Karzan A. Omar, Bakhtiyar A. Abdullah

  • Abstract

    Polyaniline was prepared by the oxidation of aniline with ammonium peroxydisulfate in present nitric acid at ambient temperature. The as-prepared polyaniline was characterized by X-ray diffraction (XRD) and FTIR. The average crystalline size of polyaniline was calculated from the XRD study. The average crystalline size of the prepared polyaniline was 7.95 nm. The antibacterial activity of 0.03 and 0.05 gm of the polyaniline was studied against Escherichia coli by the disc diffusion method, which was carried out in the absence of irradiation, and the effective antibacterial activity observed for polyaniline against Escherichia coli bacteria.

Relationships of Protein and Cyanide Content in Cassava Collected From Selected Sources in Iloilo, Philippines

Vivian Azucena-Topor

  • Abstract

    Cassava root samples were arbitrarily chosen from 14 cassava farms in 10 municipalities and 6 public markets around Iloilo, Philippines. Samples collected are of two major varieties: those with yellow roots, yellow green petiole and purple apical leaves identified as belonging to either the Golden Yellow or Lakan I variety and those with white roots, red petiole and green apical leaves belonging to the Native or Balinghoy variety. Pearson correlation revealed a significant positive linear relationship between the protein content and cyanide content in roots of Golden Yellow/Lakan I variety; while no evidence of linear relationship was observed between the cyanide and protein content in leaves; between protein content in roots and cyanide content in leaves; and also between the cyanide content in the roots and protein content in leaves. For the Native/Balinghoy variety, a significant positive linear relationship (at 0.05 level) between the cyanide content and protein content in leaves was observed between the cyanide content and protein content in roots and between the cyanide content in leaves and protein content in roots. There is no sufficient evidence to conclude that cyanide content in roots and protein content in leaves are linearly related. A curvilinear relationship between cyanide content in roots nd protein content in leaves of the Golden Yellow/Lakan I and the Native/Balinghoy varieties was observed. The relationship is positive linear for values below 40 ppm and is negative linear above it. 

Synthesis, Analytical, Spectral and DNA Binding Studies of Cu (II) Complex with 1-Phenyl-2, 3-Dimethyl-4-Aminopyrazole-5-One and Benzoate Ion

K.Rajasekar, S. Balasubramaniyan, D.Prasanth, T. Gomadurai and A. Manokaran

  • Abstract

    Transition metal complex of Cu(II) synthesized from1-phenyl-2,3-dimethyl-4-aminopyrazole-5-one (4-AAP) and benzoate ion (Benz). Synthesized complex was characterized from their elemental analysis, metal estimation, magnetic moment, molar conductance, IR, UV-Visible and EPR spectral studies. The analytical and spectral data confirmed by the composition of complex. The magnetic moment, UV-Visible, EPR spectral data of the complex suggest a tetragonally distorted octahedral geometry around Cu(II) ion. The non-electrolytic nature (1:0 type) and entry of the ligands into the coordination sphere, functional groups present in the complex were confirmed by the molar conductance and IR spectra. The DNA binding nature of Cu(II) complex with calf thymus DNA(CT-DNA method) was studied by UV-Visible absorption spectral method at 10 different concentrations. The complex shows good DNA Binding activity. 

Qualitative and Quantitative Analysis of Phytochemicals in Some Medicinal Plants in Bangladesh

Md. Tariqul Islam, Md. Abdullah Al Mamun, Md. Hassanur Rahman , Md. Atikur Rahman, Mst. Moli Akter  and Most. Sarmin Ashraf 

  • Abstract

    The objective of the present study was to find out the presence of phytochemicals in the aqueous extracts of thirteen medicinal plants Azadirachta indica, Allium sativum, Cajanus cajan, Catharanthus roseus, Calotrips procera, Cliotoria ternatea, Curcuma longa, Datura metel, Nigella sativa, Trigonella foenum-graceum, Terminalia arjuna, Vitex negunda, Zingiber officinale by both qualitative and quantitative screening methods. In qualitative analysis, the phytochemical compounds such as alkaloids, tannins, saponins, flavonoids, terpenoids, cardio glycosides, anthocyanin and steroids were screened. In quantitative analysis, the phytochemical compounds such as total phenol, flavonoids, alkaloids and saponins were quantified. Among all tested plants, Allium sativum contained significantly higher levels of total polyphenol (26.87 mg GAE/g) compared to other plant species. The flavonoids content of Zingiber officinale (266.2 mg RE/g DW) and Allium sativum (250.9 mg RE/g DW) were quite high compared to that of remaining tested plants. On the contrary Zingiber officinale contained the highest percentage crude yield of alkaloids (26.64%), while Nigella sativa contained the lowest (7.14%). The highest yield of saponin (34.17 %) contained in Terminalia arjuna while lowest (15.50 %) in T. graceum, whereas saponin was absent in Cajanus cajan and Nigella sativa plants. More active compounds will be isolated from the selected plants and a comparative study should be analyzed for medicinal purpose in future.

Determination of Apparent Molal Volume, Apparent Molal Compressibility, Relative Association And Solvation Number of Substituted-N,N’bis(Salicyliden)-Arylmethanediamines in 80% DMF+ Water System at 300K

A.S. Chandami, D.S. Hedaoo and M. P. Wadekar

  • Abstract

    The important acoustical parameters like apparent molal volume, apparent molal compressibility, relative association and solvation number of substituted-N,N’bis(salicyliden)-arylmethanediamines in binary mixture of DMF-Water was studied. The experimental data used to predict effect of concentration of ligands on these parameters, provides a valuable information regarding molecular i7teractions in binary system of 80%DMF-Water at 300K.

Synthesis, Anticonvulsant and Toxicity Evaluation of Newer 2-[4-(3-Substituted Phenylacryloyl) Phenylamino]-NSubstituted Phenyl Acetamide Derivatives

Mohammed AL-Bratty, Md Shamsher Alam, Nidhi Singh, Waquar Ahsan

  • Abstract

    A series of new 2-[4-(3-substituted phenylacryloyl)phenylamino]-Nsubstituted phenyl acetamide derivatives (3a-p) were synthesized by the reaction of 2-(4-acetylphenylamino)-N-substitutedphenylacetamide (2a-d) with substituted benzaldehyde. Synthesized compounds were characterized by their IR spectroscopy spectroscopy, 1H NMR and mass spectroscopy. The newly synthesized compounds were screened for their anticonvulsant activity using MES and scPTZ models. Compounds 3b, 3c, 3f, 3k and 3n displayed encouraging anticonvulsant profile against both the MES and sc. PTZ seizure models. Neurotoxicity studies have been done on the selected compounds through rotorod test. Utmost active compounds were studied to in vitro GABAtransaminase inhibition assay to find out the possible mechanism that may be involved in the activity. Compounds were found to be less toxic and can be treated as lead compounds for imminent studies. 

Wheland Intermediates: The Elf (Electron Localization Function) Analysis

Ibrahim Mbouombouo Ndassa, Issofa Patouossa, Abel Idrice Adjieufack, François Volatron and Bernard Silvi

  • Abstract

    The Electron Localization Function (ELF) analysis has been applied on Wheland intermediates (σ complexes) obtained from the chlorination reactions of aniline catalyzed by Aluminium Chloride. This study permits us to evaluate the electronic population on Wheland intermediates obtained from this reaction in order to explain and understand the orientation of the aromatic substitution of this substituted benzene. The results obtained explain the traditional orientation of these reactions which suggested that the orientation of the second substituent in ortho and para positions in the case of aniline depend on the stability of the intermediates Wheland complexes σ1 or σ2.

Screening of Schiff Base Benzylamine-N-(P-Methoxy Benzylidene) As Corrosion Inhibitor for Zinc in Hydrochloric Acid

Vijay Ram,Mukesh chavda, Nishaben Shah, Pragnesh Dave, Ekta Khosla

  • Abstract

    Corrosion inhibition of zinc in0.5 M and 1.0 M HCl was investigated in the absence and presence of different concentration of Benzylamine-N-(p-methoxy benzylidene) [BANPMB] by using Weight loss method. The inhibition efficiency increased with increase in inhibitor concentration but decreased with increase in temperature. The adsorption of the Schiff base was found to obey Langmuir adsorption isotherm. Some thermodynamic parameters (such as ΔGads and Qads) and activation energy (Ea) were calculated to elaborate the mechanism of corrosion inhibition.

Synthesis and Characterization of New Schiff Bases Derived from Ceftriaxone Sodium with 1H-Indole-2, 3-Dione (Isatin) and 1-Acetyl Indoline-2, 3-Dione (NAcetylisatin) and their Platinum (IV) Complexes

Ahlam Jameel Abdulghani and Saja Khalil Mohuee

  • Abstract

    Two new Schiff base ligands were prepared from condensation reaction of ceftriaxone sodium with 1H-indole-2,3-dione (Isatin) and 1-acetylindoline-2,3-dione (N-acetylisatin) and their structures were characterized by CHN analysis, 1HNMR and FT-IR spectrophotometry, mass spectra and thermal analysis. Three Platinum complexes were prepared by reaction of ceftriaxone and the two Schiff base ligands with hexachloroplatinic acid and their structures were characterized by CHN analysis, FT-IR spectrophotometry, thermal analysis, molar conductivity and atomic absorption spectrophotometry (AAS). All complexes exhibited 1:1 metal: ligand ratio. The results of electronic spectra and magnetic susceptibility measurements suggested octahedral arrangement of ligand donor atoms around the Pt(IV) ions . 

Antibacterial Evaluation of Novel Napthopyranoquinolones

Dhivya Paul and Rajendran Subramanian Parameswaran

  • Abstract

    This manuscript describes the synthesis and antibacterial activity of napthopyrano quinolones. A series of new napthopyrano quinolones were prepared in two steps from 2-chloro3-formyl quinoline and 4-methylbenzo[h]chromen-2-one. The reaction involves the use of mild reaction conditions (AcOH/AcONa) for the synthesis of styryl derivative. The styryl intermediate upon base catalysed ring closure afforded the corresponding target compounds in good yield. They have been characterized by their physical constants, Infrared, NMR and mass spectral data. These molecules were evaluated for their antibacterial activity and found to exhibit significant activity against the tested strains.

In Vitro Assessment of Antimicrobial Activity of Combretum Glutinosum Leaves Extracts (Combretaceae)

Ousmane Niass, Serigne Omar Sarr, Abdoulaye Diop, Amadou Diop, Yérim Mbagnik Diop

  • Abstract

    A plant traditionally used in medicine, namely Combretum glutinosum (Combretaceae), whose leaves are widely used as herbal tea in West Africa and its bark as antibiotics, was selected. The plant material was collected, dried, ground into fine powder, before being extracted by maceration with solvents (ethanol, methanol, and methanol/Water 50/50; v/v), and afterwards filtered and dried through evaporation. The dry extract was used to test in vitro the antibacterial activity on four different strains (Enterococcus, faecalis, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus). Among the extracts tested, those obtained with methanol showed the greatest activity, with minimum inhibitory concentrations (MIC) of 125μg/ml on Staphylococcus aureus, 250μg/ml on Enterococcus faecalis, and 500μg/ml on Pseudomonas aeruginosa and Escherichia coli which had a common MIC value.

Preconcentration and Determination of Captopril in Different Samples by Cloud Point Extraction Coupling With Uv-Visible Spectrophotometry

Jameel M. Dhabab, Taif Th. kazar

  • Abstract

    This work was influenced the separation and preconcentration steps were carried out to determination of metformin (CAP) in pharmaceutical preparations and human serum samples. Complex formation method and cloud-point extraction (CPE) coupling with UV-Visible spectrophotometry were used to investigated of study target. The results has showed the best optical characteristic for calibration curve and statistical data which were obtained under optimum conditions. The first method is based on the reaction of CAP with nickel (II) in alkaline medium an absorption maximum λ)max) at 422nm. ''Beer's low'' is obeyed in the concentration range (10-100μg.ml-1) with molar absorptivity of 1.9x104 L.mol-1.cm-1.The limit of detection and quantitation values were 1.83 and5.49 μg.ml-1 respectively. The second method based on extraction of traces amounts of CAP using the cloud-point extraction (CPE). This method implicated for using of a nonionic surfactant (Triton x-114) as an extraction medium which was entrap the hydrophobic complex formed between CAP and nickel(ii) in basic medium as reaction system for designing the CPE procedure. The optimum conditions were similar the first method expect the amount of surfactant which was 0.5 ml. The concentrations range of calibration curve from 3.5to60 μg.ml-1 and molar absorptivity of 2.1x104 L.mol-1.cm-1. In this method was access to less of concentrations in Limit of detection and quantitation which were 0.22and 0.6 μg.ml-1 respectively. The precise (RSD %) and accuracy (recovery %) of both methods were ranged between 0.9-0.7, 97.86-98.68 respectively. The data of two methods were appeared high acceptable with slandered of British Pharmacopoeia through using statistic methods (f-test and t-test), that they may be used in analysis of CAP.

Antiviral Activity of Some Novel Synthesised1, 3, 4-Oxadiazole

Mojahid ul Islam, Mohammed albratty

  • Abstract

    A series of 5-{3’-oxo-6’-(substituted aryl)-2’,3’, 4’, 5’-tetrahydropyridazin-2’-yl methyl}-2-substituted 1,3,4-oxadiazole has been synthesized. Appropriate aromatic hydrocarbon reacts with succinic anhydride in presence of AlCl3 to yield β-Aroyl propionic acid (1a). The corresponding acid is cyclised with hydrazine hydrate to give 6-(substituted aryl)-2,3,4,5-tetrahydro-3-pyridazinone (1b).This intermediate after reaction with ethyl bromo acetate, hydrazinolysed into 3-oxo-6-(substituted aryl)-2, 3, 4, 5-tetrahydropyridazinyl acetohydrazide (1c).The resulting product was converted into 5-{3’-oxo-6’-(substituted aryl)-2’,3’,4’,5’-tetrahydropyridazin-2’-yl methyl}-2-substituted 1,3,4-oxadiazole (Scheme-I). All the final compounds have been structurally elucidated on the basis of IR, 1H-NMR, mass spectral data and elemental analysis and screened for antiviral activity.

A Combined Experimental (1H, 13C NMR, FT-IR, ElectronicTransitions, Antimicrobial activity) and Computational studies on μ-oxy-bis (triphenylantimony) chloronalidixate

Surjeet Singh1, Kiran Singhal, Ram Ashish, Om Prakash, Prem Raj and S.Jamal Haider Zaidi

  • Abstract

    Organoantimony compounds have diversity of applications in both biological and non-biological fields. There has been a considerable interest centered on the chemistry of organoantimony(III) halides over the past two decades. The coordination behavior, spectral analysis and DFT study, a newly synthesized organoantimony halocarboxylate derivative has been investigated in the present work. The new 𝜇-oxy-bis(triphenylantimony)chloro nalidixate (3) has been obtained by the metathetical reaction of 𝜇-oxy-bis(triphenylantimony)dichloride with silver salt of nalidixic acid and characterized by FT-IR, 1H,13CNMR and UV-VIS spectroscopy and quantum chemical calculations. The TD–DFT calculation shows that electronic excitations are π→π* in nature. Natural bond orbital (NBO) analysis has been carried out to investigate the various conjugative / hyperconjugative interactions within molecule and stabilized the molecule upto 24.42 kcal/mol. The first hyperpolarizability (β0) has been computed to evaluate the non–linear optical (NLO) response of the investigated molecule and found to be 76.95 x 10-30 esu. The preliminary bioassay suggested that the compound (3) exhibits relatively good antibacterial activity against Escherichia coli and Staphylococcus aureus.

Oxidative Addition Reactions of Organoantimony Compounds with less common electrophiles

Ram Ashish, S. Jamal Haider Zaidi, Parul Misra and Kiran Singhal

  • Abstract

    Oxidative addition reactions of sterically hindered (α–C10H7)3Sb has been carried out with ICN, BrCN, (NH4)2PbCl6, HgCl2, TeCl4 and of (α-C10H7)2SbCl with IBr to give addition products which are characterized on the basis of spectroscopy, melting points, and representative complexes of (α-C10H7)3SbCl3 has been isolated with DMSO and alone (α-C10H7)3Sb (OAc)2 has been isolated for the first time.

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