Vol. 7 & Issue 4 ; Section A : Chemical Sciences

Date : Aug. to Oct.2017

 

Validated Derivative Spectrophotometric Methods for the Analysis of Lincomycin in Bulk and Dosage Forms

Shaza W. Shantier , Mohammed M. Elimam, Elrasheed A. Gadkariem,

JCBPS; Section A; August 2017 – October 2017, Vol. 7, No. 4; 851-856,

 

  • Abstract

    Spectrophotometric methods (zero-order, first order and second order derivative) were evaluted for the analysis of lincomycin in bulk and pharmaceutical formulation. The first and second derivative methods were found more suitable for the analysis as zero order spectrum showed non-defined λmax. Regression analysis for first and second derivative obeyed Beer’s law over the concentration range 3-15μg/ml with good correlation coefficient (not less than 0.999). The two methods were proved to be simple and sensitive (LOD and LOQ: 0.676μg/ml and 2.28μg/ml, respectively). Selectivity was reflected by the obtained recovery percentage results (100.3 ± 1.3%; n=3).

Comparative in Vitro Evaluations of Different Brands of Atenolol Tablets in Libyan Market

Mohamed M. Siaan, Massud A. S. Anwair,   Fathi Sadek, Anisa Elhamili,

JCBPS; Section A; August 2017 – October, 2017, Vol. 7, No. 4; 857-867

[DOI: 10.24214/jcbps.A.7.4.85767]

  • Abstract

    Continuation of our research studies of various pharmaceutical products in the Libyan market in order to monitor their quality, effectiveness, safety and safety of patients. So, in this study we focused on comparative in vitro evaluations of different brands of atenolol tablets and this study included some of the specifications that should be provided in medicine from appearance, thickness, diameter, weight variation, hardness, friability, disintegration time, dissolution, tensile strength, thickness and diameter, where these investigations have become widely accepted as a method of controlling of drug products and we have Prepared of standard calibration curve of atenolol by methanol for the assay and other standard calibration curve of atenolol by 0.1NHCL for the dissolution and the results data were compared them with scientific references and we found that all the visual inspection testing for all the atenolol tablets of the 3 brands were in a good condition, and each individual tablet was free from cracks and the tablets color, surface smoothness & polish were uniform on whole surface for the samples tested.

Iodometric Determination of Glucose using Chloramine-T

Vatsala U, Sumana Y. Kotian, Narayana U. Kudva N, Rajesh Acharya and K. M. Lokanatha Rai

JCBPS; Section A; August 2017 – October, 2017, Vol. 7, No. 4; 868-870.

[DOI: 10.24214/jcbps.A.7.4.86870]

  • Abstract

    In this work, we have reported a simple, cost effective and reliable method for the determination of glucose iodometrically by making use of chloramine-T (CAT). This volumetric method determines glucose instantly, thereby greatly reduces the time of determination.

Thermodynamic Study of Mild Steel Corrosion Inhibition in Sulphuric Acid Medium by Tribulus terrestris Fruit Extract

Suchitra Chaudhary, Rakesh K. Tak

JCBPS; Section A; August 2017 – October, 2017, Vol. 7, No. 4; 871-881

[DOI: 10.24214/jcbps.A.7.4.87181]

  • Abstract

    Tribulus terrestris fruit extract was studied for its inhibitory effect on corrosion of mild steel in different concentration of H2SO4 solution using mass loss method. The temperature effect on corrosion behavior with addition of plant extract was studied in temperature rang 303-333 K at 0.75N H2SO4. The inhibition efficiency increases with increase in extract concentration but decrease with increase in temperature. The adsorption mechanism of inhibition was supported by Langmuir adsorption isotherm. The obtained thermodynamic parameters revealed that adsorption of inhibitor on mild steel surface was endothermic, spontaneous and physiosorption mechanism